Regulatory Network in Protein Phosphorylation
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Substrate: CUTL1

Description: Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

Ensembl ID: ENSG00000160967

UniprotKB/SwissProt: CUTL1_HUMAN (P39880)

Function: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CUTL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CUTL1CUTL1_HUMANS322RENSA S QISQL 28.06% Swiss-Prot 55.0 View   
2CUTL1CUTL1_HUMANS1218RHSSV S DSQPC 33.23% Swiss-Prot 55.0 View   
3CUTL1CUTL1_HUMANY1232SVGTE Y SQGAS 13.21% Swiss-Prot 55.0 View   
4CUTL1CUTL1_HUMANS1233VGTEY S QGASP 18.86% Swiss-Prot 55.0 View   
5CUTL1CUTL1_HUMANS1237YSQGA S PQPQH 30.78%CDC2 HPRD:00295(in vitro)  ViewAnalyzing
6CUTL1CUTL1_HUMANS1237YSQGA S PQPQH 30.78%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
7CUTL1CUTL1_HUMANS1270QKPYP S PKTIE 32.93%CDC2 HPRD:00295(in vitro)  ViewAnalyzing
8CUTL1CUTL1_HUMANS1270QKPYP S PKTIE 32.93%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
9CUTL1CUTL1_HUMANS1312EIQAG S QGQAG 33.87% Swiss-Prot 55.0 View