|Description: ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X-chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).|
Synonyms: DBX, DDX3
Ensembl ID: ENSG00000215301
UniprotKB/SwissProt: DDX3X_HUMAN (O00571)
Function: ATP-dependent RNA helicase. Acts as a cofactor for XPO1- mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Cytoplasm. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1- dependent manner