Regulatory Network in Protein Phosphorylation
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Substrate: DDX3X

Description: ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X-chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

Synonyms: DBX, DDX3

Ensembl ID: ENSG00000215301

UniprotKB/SwissProt: DDX3X_HUMAN (O00571)

Function: ATP-dependent RNA helicase. Acts as a cofactor for XPO1- mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus speckle. Cytoplasm. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1- dependent manner
PDB:2I4I
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DDX3X

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DDX3XDDX3X_HUMANY69KDKDA Y SSFGS 18.25% HPRD:02154(in vivo)View   
2DDX3XDDX3X_HUMANY69KDKDA Y SSFGS 18.25% Phospho.ELM 7.0View   
3DDX3XDDX3X_HUMANY69KDKDA Y SSFGS 18.25% Swiss-Prot 55.0 View   
4DDX3XDDX3X_HUMANS74YSSFG S RSDSR 26.97% HPRD:02154(in vivo)View   
5DDX3XDDX3X_HUMANS74YSSFG S RSDSR 26.97% Phospho.ELM 7.0View   
6DDX3XDDX3X_HUMANS74YSSFG S RSDSR 26.97% Swiss-Prot 55.0 View   
7DDX3XDDX3X_HUMANS76SFGSR S DSRGK 41.45% Swiss-Prot 55.0 View   
8DDX3XDDX3X_HUMANS78GSRSD S RGKSS 44.15% Swiss-Prot 55.0 View   
9DDX3XDDX3X_HUMANY104RGRSD Y DGIGS 19.81% Swiss-Prot 55.0 View   
10DDX3XDDX3X_HUMANY104RGRSD Y DGIGS 19.81% Phospho.ELM 7.0View   
11DDX3XDDX3X_HUMANS125ERGGN S RWCDK 30.36% Swiss-Prot 55.0 View   
12DDX3XDDX3X_HUMANT204RYTRP T PVQKH 32.57%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
13DDX3XDDX3X_HUMANT323HLLVA T PGRLV 20.85%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
14DDX3XDDX3X_HUMANY343LDFCK Y LVLDE 11.83% Phospho.ELM 7.0View   
15DDX3XDDX3X_HUMANY343LDFCK Y LVLDE 11.83% Swiss-Prot 55.0 View   
16DDX3XDDX3X_HUMANS590RGRSK S SRFSG 28.17% Swiss-Prot 55.0 View   
17DDX3XDDX3X_HUMANS594KSSRF S GGFGA 36.58% Swiss-Prot 55.0 View