Regulatory Network in Protein Phosphorylation
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Substrate: DLG7

Description: Disks large-associated protein DLG7 (Discs large homolog 7) (Hepatomaup-regulated protein) (HURP).

Synonyms: KIAA0008

Ensembl ID: ENSG00000126787

UniprotKB/SwissProt: DLG7_HUMAN (Q15398)

Function: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DLG7

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DLG7DLG7_HUMANS67ELDET S QGLVP 21.87%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2DLG7DLG7_HUMANT219KQVPR T VSSTT 20.76% HPRD:06490(in vivo)View   
3DLG7DLG7_HUMANT219KQVPR T VSSTT 20.76% Phospho.ELM 7.0View   
4DLG7DLG7_HUMANT219KQVPR T VSSTT 20.76% Swiss-Prot 55.0 (Similarity)View   
5DLG7DLG7_HUMANT224TVSST T ARKPV 26.81% HPRD:06490(in vivo)View   
6DLG7DLG7_HUMANT224TVSST T ARKPV 26.81% Phospho.ELM 7.0View   
7DLG7DLG7_HUMANT224TVSST T ARKPV 26.81% Swiss-Prot 55.0 (Similarity)View   
8DLG7DLG7_HUMANT329QVTPM T PRSAN 19.43%CDC2 Swiss-Prot 55.0   ViewAnalyzing
9DLG7DLG7_HUMANT401NKNEA T TKNLN 31.93%CDC2 Swiss-Prot 55.0   ViewAnalyzing
10DLG7DLG7_HUMANT402KNEAT T KNLNG 25.61%CDC2 Swiss-Prot 55.0   ViewAnalyzing
11DLG7DLG7_HUMANS618FFRVE S PVKLF 31.94%CDC2 Swiss-Prot 55.0   ViewAnalyzing
12DLG7DLG7_HUMANT639SQRLG T PKSVN 31.94%CDC2 Swiss-Prot 55.0   ViewAnalyzing
13DLG7DLG7_HUMANS642LGTPK S VNKAV 31.93%CDC2 Swiss-Prot 55.0   ViewAnalyzing
14DLG7DLG7_HUMANS662PQQTT S PENAG 33.34% Swiss-Prot 55.0 View   
15DLG7DLG7_HUMANS662PQQTT S PENAG 33.34% Phospho.ELM 7.0View   
16DLG7DLG7_HUMANS662PQQTT S PENAG 33.34% HPRD:06490(in vivo)View   
17DLG7DLG7_HUMANS689IPESR S SIEDA 44.97% Swiss-Prot 55.0 View   
18DLG7DLG7_HUMANS689IPESR S SIEDA 44.97% HPRD:06490(in vivo)View   
19DLG7DLG7_HUMANS689IPESR S SIEDA 44.97% Phospho.ELM 7.0View   
20DLG7DLG7_HUMANT759LNSSI T SQDVL 23.45%CDC2 Swiss-Prot 55.0   ViewAnalyzing
21DLG7DLG7_HUMANS774EKNTA S QNSIL 28.05% Swiss-Prot 55.0 View   
22DLG7DLG7_HUMANS777TASQN S ILEEG 22.40% Phospho.ELM 7.0View   
23DLG7DLG7_HUMANS777TASQN S ILEEG 22.40% HPRD:06490(in vivo)View   
24DLG7DLG7_HUMANS777TASQN S ILEEG 22.40% Swiss-Prot 55.0 View   
25DLG7DLG7_HUMANS839NLITF S PLQPG 18.95% Phospho.ELM 7.0View   
26DLG7DLG7_HUMANS839NLITF S PLQPG 18.95%CDC2 Swiss-Prot 55.0   ViewAnalyzing