Regulatory Network in Protein Phosphorylation
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Substrate: DUT

Description: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialprecursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

Ensembl ID: ENSG00000128951

UniprotKB/SwissProt: DUT_HUMAN (P33316)

Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform DUT-N: Nucleus. Isoform DUT-M: Mitochondrion.
PDB:1Q5H
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DUT

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DUTDUT_HUMANS99ETPAI S PSKRA 25.81% Swiss-Prot 55.0 View   
2DUTDUT_HUMANS99ETPAI S PSKRA 25.81% Phospho.ELM 7.0View   
3DUTDUT_HUMANS99ETPAI S PSKRA 25.81%CDC2 HPRD:03165(in vitro;in vivo)  ViewAnalyzing