|Description: Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1).|
Ensembl ID: ENSG00000101412
UniprotKB/SwissProt: E2F1_HUMAN (Q01094)
Function: Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.