Regulatory Network in Protein Phosphorylation
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Substrate: E2F1

Description: Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3)(RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associatedprotein 1) (RBAP-1).

Synonyms: RBBP3

Ensembl ID: ENSG00000101412

UniprotKB/SwissProt: E2F1_HUMAN (Q01094)

Function: Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1H24
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of E2F1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1E2F1E2F1_HUMANS31RLLDS S QIVII 24.48%ATM Phospho.ELM 7.0  ViewAnalyzing
2E2F1E2F1_HUMANS31RLLDS S QIVII 24.48%ATM HPRD:01806(in vitro)  ViewAnalyzing
3E2F1E2F1_HUMANS31RLLDS S QIVII 24.48%ATR Phospho.ELM 7.0  ViewAnalyzing
4E2F1E2F1_HUMANS31RLLDS S QIVII 24.48%ATR HPRD:01806(in vitro)  ViewAnalyzing
5E2F1E2F1_HUMANS332SATIV S PPPSS 28.04%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
6E2F1E2F1_HUMANS332SATIV S PPPSS 28.04%CDC2 HPRD:01806(in vitro;in vivo)  ViewAnalyzing
7E2F1E2F1_HUMANS337SPPPS S PPSSL 46.75%CDC2 HPRD:01806(in vitro;in vivo)  ViewAnalyzing
8E2F1E2F1_HUMANS337SPPPS S PPSSL 46.75%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
9E2F1E2F1_HUMANS364LSRMG S LRAPV 12.82%CHK2 HPRD:01806(in vitro;in vivo)  ViewAnalyzing
10E2F1E2F1_HUMANS364LSRMG S LRAPV 12.82%CHK2 Phospho.ELM 7.0  ViewAnalyzing
11E2F1E2F1_HUMANS375DEDRL S PLVAA 19.65% Swiss-Prot 55.0 View   
12E2F1E2F1_HUMANS375DEDRL S PLVAA 19.65% Phospho.ELM 7.0View   
13E2F1E2F1_HUMANS403EFISL S PPHEA 29.60%P32780(TFIIH 62 kDa subunit) HPRD:01806(in vitro;in vivo) ViewAnalyzing
14E2F1E2F1_HUMANS403EFISL S PPHEA 29.60%CDK7 Phospho.ELM 7.0  ViewAnalyzing
15E2F1E2F1_HUMANS403EFISL S PPHEA 29.60%CDK7 HPRD:01806(in vitro)  ViewAnalyzing
16E2F1E2F1_HUMANT433DFGDL T PLDF 26.92%CDK7 HPRD:01806(in vitro)  ViewAnalyzing
17E2F1E2F1_HUMANT433DFGDL T PLDF 26.92%CDK7 Phospho.ELM 7.0  ViewAnalyzing
18E2F1E2F1_HUMANT433DFGDL T PLDF 26.92%P32780(TFIIH 62 kDa subunit) HPRD:01806(in vitro;in vivo) ViewAnalyzing