Regulatory Network in Protein Phosphorylation
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Substrate: EPB41

Description: Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

Synonyms: E41P

Ensembl ID: ENSG00000159023

UniprotKB/SwissProt: 41_HUMAN (P11171)

Function: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.
PDB:1GG3
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPB41

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPB4141_HUMANT60ASNGD T PTHED 31.33%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2EPB4141_HUMANS92LKRPK S QVSEE 38.20% Swiss-Prot 55.0 View   
3EPB4141_HUMANY222LDDTV Y ECVVE 13.00% Swiss-Prot 55.0 (Similarity)View   
4EPB4141_HUMANS521QTRQA S ALIDR 18.44%PKCb HPRD:00558(in vivo)  ViewAnalyzing
5EPB4141_HUMANS540ASKRA S RSLDG 26.83% Swiss-Prot 55.0 (Similarity)View   
6EPB4141_HUMANS542KRASR S LDGAA 28.46% Swiss-Prot 55.0 (Similarity)View   
7EPB4141_HUMANS555DSADR S PRPTS 26.30% Swiss-Prot 55.0 (Similarity)View   
8EPB4141_HUMANS578GVLDA S AKKTV 40.04%PKCb HPRD:00558(in vivo)  ViewAnalyzing
9EPB4141_HUMANY660DGENI Y IRHSN 11.95%EGFR Swiss-Prot 55.0   ViewAnalyzing
10EPB4141_HUMANY660DGENI Y IRHSN 11.95%EGFR Phospho.ELM 7.0  ViewAnalyzing
11EPB4141_HUMANY660DGENI Y IRHSN 11.95%EGFR HPRD:00558(in vitro;in vivo)  ViewAnalyzing
12EPB4141_HUMANY660DGENI Y IRHSN 11.95%EGFR HPRD:00558(in vivo)  ViewAnalyzing
13EPB4141_HUMANS712RLSTH S PFRTL 26.31%CDC2 Swiss-Prot 55.0   ViewAnalyzing