Regulatory Network in Protein Phosphorylation
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Substrate: EPN1

Description: Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitoticphosphoprotein).

Ensembl ID: ENSG00000063245

UniprotKB/SwissProt: EPN1_HUMAN (Q9Y6I3)

Function: Binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming.
PDB:1INZ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPN1EPN1_HUMANS357DPWGG S PAKPS 20.11%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2EPN1EPN1_HUMANS357DPWGG S PAKPS 20.11%CDC2 HPRD:06270(in vitro)  ViewAnalyzing
3EPN1EPN1_HUMANS357DPWGG S PAKPS 20.11%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
4EPN1EPN1_HUMANS395PTSGS S AGELE 43.76% Swiss-Prot 55.0 (Similarity)View   
5EPN1EPN1_HUMANT469SRPGP T PPGAK 48.29% Swiss-Prot 55.0 View   
6EPN1EPN1_HUMANT469SRPGP T PPGAK 48.29% Phospho.ELM 7.0View