|Description: Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitoticphosphoprotein).|
Ensembl ID: ENSG00000063245
UniprotKB/SwissProt: EPN1_HUMAN (Q9Y6I3)
Function: Binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming.