|Description: Separin (EC 22.214.171.124) (Separase) (Caspase-like protein ESPL1) (Extraspindle poles-like 1 protein).|
Synonyms: ESP1, KIAA0165
Ensembl ID: ENSG00000135476
UniprotKB/SwissProt: ESPL1_HUMAN (Q14674)
Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus.