Regulatory Network in Protein Phosphorylation
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Substrate: ESPL1

Description: Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extraspindle poles-like 1 protein).

Synonyms: ESP1, KIAA0165

Ensembl ID: ENSG00000135476

UniprotKB/SwissProt: ESPL1_HUMAN (Q14674)

Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ESPL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ESPL1ESPL1_HUMANS1073TQHLD S VKKVH 42.04% Phospho.ELM 7.0View   
2ESPL1ESPL1_HUMANS1126PSTNS S PVLKT 22.54% Swiss-Prot 55.0 View   
3ESPL1ESPL1_HUMANS1126PSTNS S PVLKT 22.54%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
4ESPL1ESPL1_HUMANS1126PSTNS S PVLKT 22.54%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
5ESPL1ESPL1_HUMANS1305KSVPG S EPSKT 40.02% Phospho.ELM 7.0View   
6ESPL1ESPL1_HUMANT1346RGLPC T PKPPD 32.19% Phospho.ELM 7.0View   
7ESPL1ESPL1_HUMANS1501NWRKM S FEILR 23.82% Phospho.ELM 7.0View   
8ESPL1ESPL1_HUMANS1508EILRG S DGEDS 35.69% Phospho.ELM 7.0View   
9ESPL1ESPL1_HUMANS1508EILRG S DGEDS 35.69% Swiss-Prot 55.0 View   
10ESPL1ESPL1_HUMANS1508EILRG S DGEDS 35.69% HPRD:06825(in vivo)View   
11ESPL1ESPL1_HUMANS1545KKKLP S PCPDK 49.96% Phospho.ELM 7.0View   
12ESPL1ESPL1_HUMANS1552CPDKE S DKDLG 56.55% Phospho.ELM 7.0View