Regulatory Network in Protein Phosphorylation
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Substrate: ESR1

Description: Estrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1).

Synonyms: ESR, NR3A1

Ensembl ID: ENSG00000091831

UniprotKB/SwissProt: ESR1_HUMAN (P03372)

Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ESR1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ESR1ESR1_HUMANT7TMTLH T KASGM 31.27% Swiss-Prot 55.0 View   
2ESR1ESR1_HUMANS10LHTKA S GMALL 30.56% Swiss-Prot 55.0 View   
3ESR1ESR1_HUMANS102FPPLN S VSPSP 31.49%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
4ESR1ESR1_HUMANS102FPPLN S VSPSP 31.49%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing
5ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
6ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%CDK2 Swiss-Prot 55.0   ViewAnalyzing
7ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%CDK_group Phospho.ELM 7.0 ViewAnalyzing
8ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing
9ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing
11ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
12ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%CDK2 Swiss-Prot 55.0   ViewAnalyzing
13ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
14ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%RSK3 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
15ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%Erk2 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
16ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
17ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
18ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
19ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36% Swiss-Prot 55.0 View   
20ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%CDK7 HPRD:00589(in vivo)  ViewAnalyzing
21ESR1ESR1_HUMANS118PPPQL S PFLQP 14.36%CDK7 Phospho.ELM 7.0  ViewAnalyzing
22ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%AKT1 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
23ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%AKT_group Phospho.ELM 7.0 ViewAnalyzing
24ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%Akt2(PKB beta) Phospho.ELM 7.0 ViewAnalyzing
25ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%AKT2 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
26ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%CK2_group Swiss-Prot 55.0  ViewAnalyzing
27ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%RSK_group Phospho.ELM 7.0 ViewAnalyzing
28ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%CK2_group Phospho.ELM 7.0 ViewAnalyzing
29ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%RSK3 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
30ESR1ESR1_HUMANS167RERLA S TNDKG 32.13%RSK2 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
31ESR1ESR1_HUMANS236KNRRK S CQACR 15.06%PKA_group Phospho.ELM 7.0 ViewAnalyzing
32ESR1ESR1_HUMANS305RSKKN S LALSL 24.73%PAK1 HPRD:00589(in vitro;in vivo)  ViewAnalyzing
33ESR1ESR1_HUMANS305RSKKN S LALSL 24.73%PAK1 Phospho.ELM 7.0  ViewAnalyzing
34ESR1ESR1_HUMANT311LALSL T ADQMV 25.47%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
35ESR1ESR1_HUMANT311LALSL T ADQMV 25.47%p38a HPRD:00589(in vitro;in vivo)  ViewAnalyzing
36ESR1ESR1_HUMANT311LALSL T ADQMV 25.47%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
37ESR1ESR1_HUMANY537NVVPL Y DLLLE 9.85%Tyr-kinases Swiss-Prot 55.0  ViewAnalyzing
38ESR1ESR1_HUMANY537NVVPL Y DLLLE 9.85%Lck Phospho.ELM 7.0  ViewAnalyzing
39ESR1ESR1_HUMANY537NVVPL Y DLLLE 9.85%LCK HPRD:00589(in vitro;in vivo)  ViewAnalyzing
40ESR1ESR1_HUMANY537NVVPL Y DLLLE 9.85%Src Phospho.ELM 7.0  ViewAnalyzing
41ESR1ESR1_HUMANY537NVVPL Y DLLLE 9.85%SRC HPRD:00589(in vitro;in vivo)  ViewAnalyzing