Regulatory Network in Protein Phosphorylation
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Substrate: FEN1

Description: Flap endonuclease 1 (EC 3.1.-.-) (Flap structure-specific endonuclease1) (FEN-1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV).

Synonyms: RAD2

Ensembl ID: ENSG00000168496

UniprotKB/SwissProt: FEN1_HUMAN (P39748)

Function: Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Also possesses 5' to 3' exonuclease activity on niked or gapped double-stranded DNA, and exhibits RNase H activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1U7B
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FEN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FEN1FEN1_HUMANS187CLTFG S PVLMR 13.98%CDC2 HPRD:02670(in vitro)  ViewAnalyzing
2FEN1FEN1_HUMANS187CLTFG S PVLMR 13.98%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing