|Description: Flap endonuclease 1 (EC 3.1.-.-) (Flap structure-specific endonuclease1) (FEN-1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV).|
Ensembl ID: ENSG00000168496
UniprotKB/SwissProt: FEN1_HUMAN (P39748)
Function: Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Also possesses 5' to 3' exonuclease activity on niked or gapped double-stranded DNA, and exhibits RNase H activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.