|Description: Protein HIRA (TUP1-like enhancer of split protein 1).|
Synonyms: DGCR1, HIR, TUPLE1
Ensembl ID: ENSG00000100084
UniprotKB/SwissProt: HIRA_HUMAN (P54198)
Function: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.