Regulatory Network in Protein Phosphorylation
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Substrate: HIRA

Description: Protein HIRA (TUP1-like enhancer of split protein 1).

Synonyms: DGCR1, HIR, TUPLE1

Ensembl ID: ENSG00000100084

UniprotKB/SwissProt: HIRA_HUMAN (P54198)

Function: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
PDB:2I32
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HIRA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HIRAHIRA_HUMANT555PSVLT T PSKIE 22.77%CDK2 Swiss-Prot 55.0   ViewAnalyzing
2HIRAHIRA_HUMANT555PSVLT T PSKIE 22.77%CDK2 HPRD:02583(in vitro;in vivo)  ViewAnalyzing
3HIRAHIRA_HUMANT555PSVLT T PSKIE 22.77%CDK2 Phospho.ELM 7.0  ViewAnalyzing
4HIRAHIRA_HUMANS687KLPIP S PQRAF 34.09% Swiss-Prot 55.0 View   
5HIRAHIRA_HUMANS687KLPIP S PQRAF 34.09% Phospho.ELM 7.0View   
6HIRAHIRA_HUMANS687KLPIP S PQRAF 34.09%CDK2 HPRD:02583(in vitro;in vivo)  ViewAnalyzing