Regulatory Network in Protein Phosphorylation
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Substrate: HTATIP

Description: Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDaTat interactive protein) (Tip60) (HIV-1 Tat interactive protein)(cPLA(2)-interacting protein).

Synonyms: TIP60

Ensembl ID: ENSG00000172977

UniprotKB/SwissProt: TIP60_HUMAN (Q92993)

Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to HTATIP polyubiquitination and targets it to degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region.
PDB:2OU2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HTATIP

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HTATIPTIP60_HUMANS86NGLPG S RPGSP 33.10% Swiss-Prot 55.0 View   
2HTATIPTIP60_HUMANS86NGLPG S RPGSP 33.10%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3HTATIPTIP60_HUMANS86NGLPG S RPGSP 33.10%CDC2 HPRD:03245(in vitro;in vivo)  ViewAnalyzing
4HTATIPTIP60_HUMANS86NGLPG S RPGSP 33.10%P14635(Cyclin B1) HPRD:03245(in vitro;in vivo) ViewAnalyzing
5HTATIPTIP60_HUMANS90GSRPG S PEREV 26.69%CDC2 Swiss-Prot 55.0   ViewAnalyzing
6HTATIPTIP60_HUMANS90GSRPG S PEREV 26.69%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
7HTATIPTIP60_HUMANS90GSRPG S PEREV 26.69%CDC2 HPRD:03245(in vitro;in vivo)  ViewAnalyzing
8HTATIPTIP60_HUMANS90GSRPG S PEREV 26.69%P14635(Cyclin B1) HPRD:03245(in vitro;in vivo) ViewAnalyzing