Regulatory Network in Protein Phosphorylation
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Substrate: ID3

Description: DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID-like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1).

Synonyms: 1R21, HEIR-1

Ensembl ID: ENSG00000117318

UniprotKB/SwissProt: ID3_HUMAN (Q02535)

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ID3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ID3ID3_HUMANS5-MKAL S PVRGC 26.64%CDK2 HPRD:02608(in vitro;in vivo)  ViewAnalyzing
2ID3ID3_HUMANS5-MKAL S PVRGC 26.64%CDK2 Phospho.ELM 7.0  ViewAnalyzing