Regulatory Network in Protein Phosphorylation
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Substrate: KHDRBS1

Description: KH domain-containing, RNA-binding, signal transduction-associatedprotein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68kDa protein) (Sam68) (p68).

Synonyms: SAM68

UniprotKB/SwissProt: KHDR1_HUMAN (Q07666)

Function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Membrane.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KHDRBS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KHDRBS1KHDR1_HUMANS18RSSGR S GSMDP 38.45% Swiss-Prot 55.0 View   
2KHDRBS1KHDR1_HUMANS20SGRSG S MDPSG 22.66% Swiss-Prot 55.0 View   
3KHDRBS1KHDR1_HUMANS20SGRSG S MDPSG 22.66% Phospho.ELM 7.0View   
4KHDRBS1KHDR1_HUMANS20SGRSG S MDPSG 22.66% HPRD:03926(in vivo)View   
5KHDRBS1KHDR1_HUMANT33PSVRQ T PSRQP 16.80% Swiss-Prot 55.0 View   
6KHDRBS1KHDR1_HUMANS58GGARA S PATQP 14.98%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
7KHDRBS1KHDR1_HUMANS58GGARA S PATQP 14.98%Erk2 HPRD:03926(in vitro)  ViewAnalyzing
8KHDRBS1KHDR1_HUMANT84GGPAP T PLLPP 28.77%Erk2 HPRD:03926(in vitro)  ViewAnalyzing
9KHDRBS1KHDR1_HUMANT84GGPAP T PLLPP 28.77%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
10KHDRBS1KHDR1_HUMANY103EPENK Y LPELM 38.79% Phospho.ELM 7.0View   
11KHDRBS1KHDR1_HUMANT317ALVRG T PVRGA 14.19%CDC2 HPRD:03926(in vitro;in vivo)  ViewAnalyzing
12KHDRBS1KHDR1_HUMANT317ALVRG T PVRGA 14.19%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
13KHDRBS1KHDR1_HUMANY435PVKGA Y REHPY 25.79%BRK HPRD:03926(in vivo)  ViewAnalyzing
14KHDRBS1KHDR1_HUMANY440YREHP Y GRY 19.01%BRK HPRD:03926(in vivo)  ViewAnalyzing
15KHDRBS1KHDR1_HUMANY443HPYGR Y  20.67%BRK HPRD:03926(in vivo)  ViewAnalyzing