Regulatory Network in Protein Phosphorylation
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Substrate: KIF11

Description: Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5)(Kinesin-like spindle protein HKSP) (Thyroid receptor-interactingprotein 5) (TRIP-5) (Kinesin-like protein 1).

Synonyms: EG5, KNSL1, TRIP5

Ensembl ID: ENSG00000138160

UniprotKB/SwissProt: KIF11_HUMAN (P52732)

Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KIF11

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KIF11KIF11_HUMANT458DLQNK T QELET 34.52% Swiss-Prot 55.0 View   
2KIF11KIF11_HUMANT926IPTGT T PQRKS 20.83%CDC2 Swiss-Prot 55.0   ViewAnalyzing
3KIF11KIF11_HUMANT926IPTGT T PQRKS 20.83%CDK_group Phospho.ELM 7.0 ViewAnalyzing
4KIF11KIF11_HUMANT926IPTGT T PQRKS 20.83%CDC2 HPRD:01023(in vitro;in vivo)  ViewAnalyzing
5KIF11KIF11_HUMANT926IPTGT T PQRKS 20.83%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
6KIF11KIF11_HUMANS931TPQRK S YLYPS 23.66% Swiss-Prot 55.0 View   
7KIF11KIF11_HUMANS931TPQRK S YLYPS 23.66% Phospho.ELM 7.0View   
8KIF11KIF11_HUMANS931TPQRK S YLYPS 23.66% HPRD:01023(in vivo)View