Regulatory Network in Protein Phosphorylation
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Substrate: LATS1

Description: Serine/threonine-protein kinase LATS1 (EC (Large tumorsuppressor homolog 1) (WARTS protein kinase) (h-warts).

Synonyms: WARTS

Ensembl ID: ENSG00000131023

UniprotKB/SwissProt: LATS1_HUMAN (O95835)

Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LATS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LATS1LATS1_HUMANS244PPQVR S VTPPP 31.33% Swiss-Prot 55.0 View   
2LATS1LATS1_HUMANS244PPQVR S VTPPP 31.33% Phospho.ELM 7.0View   
3LATS1LATS1_HUMANS464PVRSN S FNNPL 30.51% HPRD:09147(in vitro)View   
4LATS1LATS1_HUMANS464PVRSN S FNNPL 30.51% Phospho.ELM 7.0View   
5LATS1LATS1_HUMANS464PVRSN S FNNPL 30.51% Swiss-Prot 55.0 (Similarity)View   
6LATS1LATS1_HUMANT490TVTAI T PAPIQ 15.78%CDC2 HPRD:09147(in vitro)  ViewAnalyzing
7LATS1LATS1_HUMANS613KQITT S PITVR 12.98%CDC2 HPRD:09147(in vitro;in vivo)  ViewAnalyzing
8LATS1LATS1_HUMANS613KQITT S PITVR 12.98% Phospho.ELM 7.0View   
9LATS1LATS1_HUMANS633ESRIQ S YSPQA 25.80% Phospho.ELM 7.0View   
10LATS1LATS1_HUMANS674MRVGL S QDAQD 21.78% Swiss-Prot 55.0 View   
11LATS1LATS1_HUMANS909RCLAH S LVGTP 21.10% Phospho.ELM 7.0View   
12LATS1LATS1_HUMANS909RCLAH S LVGTP 21.10%MST2(STK3) Swiss-Prot 55.0  ViewAnalyzing
13LATS1LATS1_HUMANT1079AFYEF T FRRFF 12.32% Phospho.ELM 7.0View   
14LATS1LATS1_HUMANT1079AFYEF T FRRFF 12.32%MST2(STK3) Swiss-Prot 55.0  ViewAnalyzing
15LATS1LATS1_HUMANS1111GSEQQ S DEDDQ 42.53% Phospho.ELM 7.0View