|Description: Serine/threonine-protein kinase LATS1 (EC 184.108.40.206) (Large tumorsuppressor homolog 1) (WARTS protein kinase) (h-warts).|
Ensembl ID: ENSG00000131023
UniprotKB/SwissProt: LATS1_HUMAN (O95835)
Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.