Regulatory Network in Protein Phosphorylation
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Substrate: LMNA

Description: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32).

Synonyms: LMN1

Ensembl ID: ENSG00000160789

UniprotKB/SwissProt: LMNA_HUMAN (P02545)

Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LMNA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LMNALMNA_HUMANS5-METP S QRRAT 43.68%PKC_group Phospho.ELM 7.0 ViewAnalyzing
2LMNALMNA_HUMANT10SQRRA T RSGAQ 24.45% Swiss-Prot 55.0 View   
3LMNALMNA_HUMANT10SQRRA T RSGAQ 24.45% Phospho.ELM 7.0View   
4LMNALMNA_HUMANS12RRATR S GAQAS 33.84% Swiss-Prot 55.0 (Similarity)View   
5LMNALMNA_HUMANT19AQASS T PLSPT 26.25%CDC2 HPRD:01035(in vitro;in vivo)  ViewAnalyzing
6LMNALMNA_HUMANT19AQASS T PLSPT 26.25% Swiss-Prot 55.0 View   
7LMNALMNA_HUMANT19AQASS T PLSPT 26.25%CDK_group Phospho.ELM 7.0 ViewAnalyzing
8LMNALMNA_HUMANT19AQASS T PLSPT 26.25%PKCa HPRD:01035(in vitro;in vivo)  ViewAnalyzing
9LMNALMNA_HUMANS22SSTPL S PTRIT 25.98%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10LMNALMNA_HUMANS22SSTPL S PTRIT 25.98%CDC2 HPRD:01035(in vitro;in vivo)  ViewAnalyzing
11LMNALMNA_HUMANS22SSTPL S PTRIT 25.98% Swiss-Prot 55.0 View   
12LMNALMNA_HUMANT199ENRLQ T MKEEL 34.50%PKC_group Phospho.ELM 7.0 ViewAnalyzing
13LMNALMNA_HUMANS277DNARQ S AERNS 26.92% Phospho.ELM 7.0View   
14LMNALMNA_HUMANS277DNARQ S AERNS 26.92% Swiss-Prot 55.0 View   
15LMNALMNA_HUMANS390ERLRL S PSPTS 19.52% Phospho.ELM 7.0View   
16LMNALMNA_HUMANS390ERLRL S PSPTS 19.52% HPRD:01035(in vivo)View   
17LMNALMNA_HUMANS390ERLRL S PSPTS 19.52% Swiss-Prot 55.0 View   
18LMNALMNA_HUMANS392LRLSP S PTSQR 37.12% HPRD:01035(in vivo)View   
19LMNALMNA_HUMANS392LRLSP S PTSQR 37.12% Phospho.ELM 7.0View   
20LMNALMNA_HUMANS392LRLSP S PTSQR 37.12%CDC2 HPRD:01035(in vitro;in vivo)  ViewAnalyzing
21LMNALMNA_HUMANS392LRLSP S PTSQR 37.12% Swiss-Prot 55.0 View   
22LMNALMNA_HUMANS395SPSPT S QRSRG 27.29% Phospho.ELM 7.0View   
23LMNALMNA_HUMANS395SPSPT S QRSRG 27.29% Swiss-Prot 55.0 View   
24LMNALMNA_HUMANS403SRGRA S SHSSQ 27.50%PKCa HPRD:01035(in vitro;in vivo)  ViewAnalyzing
25LMNALMNA_HUMANS403SRGRA S SHSSQ 27.50%PKC_group Phospho.ELM 7.0 ViewAnalyzing
26LMNALMNA_HUMANS403SRGRA S SHSSQ 27.50% Swiss-Prot 55.0 View   
27LMNALMNA_HUMANS404RGRAS S HSSQT 26.80% Swiss-Prot 55.0 View   
28LMNALMNA_HUMANS404RGRAS S HSSQT 26.80%PKC_group Phospho.ELM 7.0 ViewAnalyzing
29LMNALMNA_HUMANS404RGRAS S HSSQT 26.80%PKCa HPRD:01035(in vivo)  ViewAnalyzing
30LMNALMNA_HUMANS406RASSH S SQTQG 26.53% Swiss-Prot 55.0 View   
31LMNALMNA_HUMANS406RASSH S SQTQG 26.53% Phospho.ELM 7.0View   
32LMNALMNA_HUMANS406RASSH S SQTQG 26.53% HPRD:01035(in vivo)View   
33LMNALMNA_HUMANS407ASSHS S QTQGG 31.65% Phospho.ELM 7.0View   
34LMNALMNA_HUMANS407ASSHS S QTQGG 31.65% Swiss-Prot 55.0 View   
35LMNALMNA_HUMANS407ASSHS S QTQGG 31.65% HPRD:01035(in vivo)View   
36LMNALMNA_HUMANT409SHSSQ T QGGGS 31.00% HPRD:01035(in vivo)View   
37LMNALMNA_HUMANT409SHSSQ T QGGGS 31.00% Phospho.ELM 7.0View   
38LMNALMNA_HUMANT409SHSSQ T QGGGS 31.00% Swiss-Prot 55.0 View   
39LMNALMNA_HUMANS414TQGGG S VTKKR 29.86% Swiss-Prot 55.0 View   
40LMNALMNA_HUMANS414TQGGG S VTKKR 29.86% Phospho.ELM 7.0View   
41LMNALMNA_HUMANT416GGGSV T KKRKL 32.33%PKC_group Phospho.ELM 7.0 ViewAnalyzing
42LMNALMNA_HUMANT416GGGSV T KKRKL 32.33% Swiss-Prot 55.0 View   
43LMNALMNA_HUMANS423KRKLE S TESRS 48.16% Swiss-Prot 55.0 View   
44LMNALMNA_HUMANS423KRKLE S TESRS 48.16% Phospho.ELM 7.0View   
45LMNALMNA_HUMANS423KRKLE S TESRS 48.16% HPRD:01035(in vivo)View   
46LMNALMNA_HUMANT424RKLES T ESRSS 28.71% Phospho.ELM 7.0View   
47LMNALMNA_HUMANT424RKLES T ESRSS 28.71% Swiss-Prot 55.0 View   
48LMNALMNA_HUMANT480DDPLL T YRFPP 21.97%PKC_group Phospho.ELM 7.0 ViewAnalyzing
49LMNALMNA_HUMANT496AGQVV T IWAAG 16.37% Swiss-Prot 55.0 (Similarity)View   
50LMNALMNA_HUMANT505AGAGA T HSPPT 23.20% Swiss-Prot 55.0 (Similarity)View   
51LMNALMNA_HUMANS507AGATH S PPTDL 28.37% Swiss-Prot 55.0 (Similarity)View   
52LMNALMNA_HUMANT510THSPP T DLVWK 45.40% Swiss-Prot 55.0 (Similarity)View   
53LMNALMNA_HUMANS525WGCGN S LRTAL 12.43%PKCa HPRD:01035(in vivo)  ViewAnalyzing
54LMNALMNA_HUMANS525WGCGN S LRTAL 12.43% Phospho.ELM 7.0View   
55LMNALMNA_HUMANS625VTVTR S YRSVG 18.61%PKC_group Phospho.ELM 7.0 ViewAnalyzing
56LMNALMNA_HUMANS628TRSYR S VGGSG 19.51% Swiss-Prot 55.0 View   
57LMNALMNA_HUMANS628TRSYR S VGGSG 19.51% Phospho.ELM 7.0View   
58LMNALMNA_HUMANS632RSVGG S GGGSF 28.47% Swiss-Prot 55.0 View   
59LMNALMNA_HUMANS636GSGGG S FGDNL 29.36% Swiss-Prot 55.0 View   
60LMNALMNA_HUMANS636GSGGG S FGDNL 29.36% Phospho.ELM 7.0View   
61LMNALMNA_HUMANS652LLGNS S PRTQS 23.54% HPRD:01035(in vivo)View   
62LMNALMNA_HUMANS652LLGNS S PRTQS 23.54% Swiss-Prot 55.0 View