Regulatory Network in Protein Phosphorylation
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Substrate: MEF2C

Description: Myocyte-specific enhancer factor 2C.

Ensembl ID: ENSG00000081189

UniprotKB/SwissProt: MEF2C_HUMAN (Q06413)

Function: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MEF2C

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MEF2CMEF2C_HUMANS59LFQYA S TDMDK 21.72%CK2_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2MEF2CMEF2C_HUMANS59LFQYA S TDMDK 21.72%CK2a1 HPRD:02809(in vitro;in vivo)  ViewAnalyzing
3MEF2CMEF2C_HUMANS59LFQYA S TDMDK 21.72%CK2a1-rs HPRD:02809(in vitro;in vivo)  ViewAnalyzing
4MEF2CMEF2C_HUMANS59LFQYA S TDMDK 21.72%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5MEF2CMEF2C_HUMANT293AQSLA T PVVSV 23.16%p38a HPRD:02809(in vitro;in vivo)  ViewAnalyzing
6MEF2CMEF2C_HUMANT293AQSLA T PVVSV 23.16%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
7MEF2CMEF2C_HUMANT300VVSVA T PTLPG 18.04%p38a HPRD:02809(in vitro)  ViewAnalyzing
8MEF2CMEF2C_HUMANT300VVSVA T PTLPG 18.04%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
9MEF2CMEF2C_HUMANS387LPSTQ S LNIKS 24.38%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
10MEF2CMEF2C_HUMANS387LPSTQ S LNIKS 24.38%p38a HPRD:02809(in vivo)  ViewAnalyzing
11MEF2CMEF2C_HUMANS387LPSTQ S LNIKS 24.38%Erk5 HPRD:02809(in vitro;in vivo)  ViewAnalyzing
12MEF2CMEF2C_HUMANS387LPSTQ S LNIKS 24.38%Erk5(MAPK7) Phospho.ELM 7.0 ViewAnalyzing
13MEF2CMEF2C_HUMANS396KSEPV S PPRDR 39.64%CDC2 HPRD:02809(in vitro)  ViewAnalyzing
14MEF2CMEF2C_HUMANS396KSEPV S PPRDR 39.64%P14635(Cyclin B1) HPRD:02809(in vitro) ViewAnalyzing
15MEF2CMEF2C_HUMANS396KSEPV S PPRDR 39.64% Swiss-Prot 55.0 View