Regulatory Network in Protein Phosphorylation
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Substrate: NCAPD2

Description: Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2)(Chromosome condensation-related SMC-associated protein 1)(Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

Synonyms: CAPD2, CNAP1, KIAA0159

Ensembl ID: ENSG00000010292

UniprotKB/SwissProt: CND1_HUMAN (Q15021)

Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NCAPD2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NCAPD2CND1_HUMANT103AILDD T TLSGS 29.33% Phospho.ELM 7.0View   
2NCAPD2CND1_HUMANT103AILDD T TLSGS 29.33% Swiss-Prot 55.0 View   
3NCAPD2CND1_HUMANT577GPAAS T QEKNP 35.70% Swiss-Prot 55.0 View   
4NCAPD2CND1_HUMANS585KNPRE S TGNMV 42.78% Phospho.ELM 7.0View   
5NCAPD2CND1_HUMANS585KNPRE S TGNMV 42.78% Swiss-Prot 55.0 View   
6NCAPD2CND1_HUMANS1310IGQAG S QRAPS 21.36% Swiss-Prot 55.0 View   
7NCAPD2CND1_HUMANS1330YQPLA S TASDN 31.99% Phospho.ELM 7.0View   
8NCAPD2CND1_HUMANS1330YQPLA S TASDN 31.99% Swiss-Prot 55.0 View   
9NCAPD2CND1_HUMANT1331QPLAS T ASDND 25.27% Swiss-Prot 55.0 View   
10NCAPD2CND1_HUMANT1331QPLAS T ASDND 25.27% Phospho.ELM 7.0View   
11NCAPD2CND1_HUMANS1333LASTA S DNDFV 36.71% Phospho.ELM 7.0View   
12NCAPD2CND1_HUMANS1333LASTA S DNDFV 36.71% Swiss-Prot 55.0 View   
13NCAPD2CND1_HUMANT1339DNDFV T PEPRR 23.17%CDC2  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
14NCAPD2CND1_HUMANS1366PKVVF S SDESS 25.85% Swiss-Prot 55.0 View   
15NCAPD2CND1_HUMANS1367KVVFS S DESSE 33.65% Swiss-Prot 55.0 View   
16NCAPD2CND1_HUMANS1370FSSDE S SEEDL 48.30% Swiss-Prot 55.0 View   
17NCAPD2CND1_HUMANS1371SSDES S EEDLS 42.85% Swiss-Prot 55.0 View   
18NCAPD2CND1_HUMANS1376SEEDL S AEMTE 34.21% Swiss-Prot 55.0 View   
19NCAPD2CND1_HUMANT1384MTEDE T PKKTT 53.37%CDC2  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
20NCAPD2CND1_HUMANT1388ETPKK T TPILR 43.88% Swiss-Prot 55.0 View   
21NCAPD2CND1_HUMANT1388ETPKK T TPILR 43.88% Phospho.ELM 7.0View   
22NCAPD2CND1_HUMANT1389TPKKT T PILRA 19.74%CDC2  Swiss-Prot 55.0 (Similarity) ViewAnalyzing