Regulatory Network in Protein Phosphorylation
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Substrate: NDE1

Description: Nuclear distribution protein nudE homolog 1 (NudE).

Synonyms: NUDE

Ensembl ID: ENSG00000072864

UniprotKB/SwissProt: NDE1_HUMAN (Q9NXR1)

Function: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Centrosome. Kinetochore. Spindle. Note=Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase. Also localizes to the cleavage furrow during cytokinesis (By similarity). Localizes to t
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NDE1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NDE1NDE1_HUMANT215GSVPS T PIAHR 16.79%Erk2 HPRD:14815(in vitro)  ViewAnalyzing
2NDE1NDE1_HUMANT215GSVPS T PIAHR 16.79%CDC2 HPRD:14815(in vitro)  ViewAnalyzing
3NDE1NDE1_HUMANS239RGLDD S TGGTP 28.72%CDC2 HPRD:14815(in vitro)  ViewAnalyzing
4NDE1NDE1_HUMANS239RGLDD S TGGTP 28.72%Erk2 HPRD:14815(in vitro)  ViewAnalyzing
5NDE1NDE1_HUMANT246GGTPL T PAARI 16.46% Swiss-Prot 55.0 (Similarity)View   
6NDE1NDE1_HUMANY279CRNLV Y DQSPN 16.07% Phospho.ELM 7.0View   
7NDE1NDE1_HUMANY279CRNLV Y DQSPN 16.07% Swiss-Prot 55.0 View   
8NDE1NDE1_HUMANS282LVYDQ S PNRTG 22.65% Swiss-Prot 55.0 View   
9NDE1NDE1_HUMANS306GERRP S STSVP 44.42% Swiss-Prot 55.0 View   
10NDE1NDE1_HUMANS307ERRPS S TSVPL 27.64% Swiss-Prot 55.0 View