Regulatory Network in Protein Phosphorylation
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Substrate: NDEL1

Description: Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1).


Ensembl ID: ENSG00000166579

UniprotKB/SwissProt: NDEL1_HUMAN (Q9GZM8)

Function: Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL (By similarity). Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Centrosome. Spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids (By similarit
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NDEL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NDEL1NDEL1_HUMANS198KSAPS S PTLDC 22.35%CDK5 HPRD:06340(in vitro)  ViewAnalyzing
2NDEL1NDEL1_HUMANS215VQASL S LPATP 29.79% Swiss-Prot 55.0 (Similarity)View   
3NDEL1NDEL1_HUMANT219LSLPA T PVGKG 19.30%CDK5 HPRD:06340(in vitro)  ViewAnalyzing
4NDEL1NDEL1_HUMANT219LSLPA T PVGKG 19.30%Erk2(MAPK1) Swiss-Prot 55.0  ViewAnalyzing
5NDEL1NDEL1_HUMANT219LSLPA T PVGKG 19.30%CDC2 Swiss-Prot 55.0   ViewAnalyzing
6NDEL1NDEL1_HUMANS231ENTFP S PKAIP 34.54%CDK5 HPRD:06340(in vitro)  ViewAnalyzing
7NDEL1NDEL1_HUMANS242NGFGT S PLTPS 20.49%CDC2 Swiss-Prot 55.0   ViewAnalyzing
8NDEL1NDEL1_HUMANS242NGFGT S PLTPS 20.49%CDK5 HPRD:06340(in vitro)  ViewAnalyzing
9NDEL1NDEL1_HUMANT245GTSPL T PSARI 20.69%CDC2 Swiss-Prot 55.0   ViewAnalyzing
10NDEL1NDEL1_HUMANT245GTSPL T PSARI 20.69%Erk2(MAPK1) Swiss-Prot 55.0  ViewAnalyzing
11NDEL1NDEL1_HUMANT245GTSPL T PSARI 20.69%CDK5 HPRD:06340(in vitro)  ViewAnalyzing