|Description: Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1).|
Synonyms: EOPA, MITAP1, NUDEL
Ensembl ID: ENSG00000166579
UniprotKB/SwissProt: NDEL1_HUMAN (Q9GZM8)
Function: Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL (By similarity). Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Centrosome. Spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids (By similarit