Regulatory Network in Protein Phosphorylation
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Substrate: NPM1

Description: Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38).

Synonyms: NPM

Ensembl ID: ENSG00000181163

UniprotKB/SwissProt: NPM_HUMAN (P06748)

Function: Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with s
PDB:2P1B
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NPM1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NPM1NPM_HUMANS4--MED S MDMDM 11.90% Swiss-Prot 55.0 View   
2NPM1NPM_HUMANS4--MED S MDMDM 11.90%PLK1 HPRD:01246(in vitro;in vivo)  ViewAnalyzing
3NPM1NPM_HUMANS4--MED S MDMDM 11.90%PLK1 HPRD:01246(in vivo)  ViewAnalyzing
4NPM1NPM_HUMANS4--MED S MDMDM 11.90%PLK1 Phospho.ELM 7.0  ViewAnalyzing
5NPM1NPM_HUMANS10MDMDM S PLRPQ 19.27% Swiss-Prot 55.0 View   
6NPM1NPM_HUMANS10MDMDM S PLRPQ 19.27% Phospho.ELM 7.0View   
7NPM1NPM_HUMANS70MNYEG S PIKVT 16.12% HPRD:01246(in vivo)View   
8NPM1NPM_HUMANS70MNYEG S PIKVT 16.12% Phospho.ELM 7.0View   
9NPM1NPM_HUMANS70MNYEG S PIKVT 16.12% Swiss-Prot 55.0 View   
10NPM1NPM_HUMANT75SPIKV T LATLK 12.98% Swiss-Prot 55.0 View   
11NPM1NPM_HUMANT95GGFEI T PPVVL 17.84% Phospho.ELM 7.0View   
12NPM1NPM_HUMANT95GGFEI T PPVVL 17.84% Swiss-Prot 55.0 View   
13NPM1NPM_HUMANS106RLKCG S GPVHI 49.77% Swiss-Prot 55.0 (Similarity)View   
14NPM1NPM_HUMANS125EEDAE S EDEEE 52.66% Swiss-Prot 55.0 View   
15NPM1NPM_HUMANS125EEDAE S EDEEE 52.66% HPRD:01246(in vivo)View   
16NPM1NPM_HUMANS125EEDAE S EDEEE 52.66% Phospho.ELM 7.0View   
17NPM1NPM_HUMANS137DVKLL S ISGKR 25.74% Swiss-Prot 55.0 View   
18NPM1NPM_HUMANT199KSIRD T PAKNA 18.46%CDK2 HPRD:01246(in vitro;in vivo)  ViewAnalyzing
19NPM1NPM_HUMANT199KSIRD T PAKNA 18.46%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
20NPM1NPM_HUMANT199KSIRD T PAKNA 18.46% Swiss-Prot 55.0 View   
21NPM1NPM_HUMANT219SKPSS T PRSKG 27.36%CDC2 HPRD:01246(in vitro;in vivo)  ViewAnalyzing
22NPM1NPM_HUMANT219SKPSS T PRSKG 27.36% Phospho.ELM 7.0View   
23NPM1NPM_HUMANS227SKGQE S FKKQE 34.18%PKC_group Phospho.ELM 7.0 ViewAnalyzing
24NPM1NPM_HUMANS227SKGQE S FKKQE 34.18% HPRD:01246(in vitro)View   
25NPM1NPM_HUMANT234KKQEK T PKTPK 29.30% Swiss-Prot 55.0 View   
26NPM1NPM_HUMANT234KKQEK T PKTPK 29.30%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
27NPM1NPM_HUMANT234KKQEK T PKTPK 29.30%CDC2 HPRD:01246(in vitro;in vivo)  ViewAnalyzing
28NPM1NPM_HUMANT237EKTPK T PKGPS 31.28%CDC2 HPRD:01246(in vitro;in vivo)  ViewAnalyzing
29NPM1NPM_HUMANT237EKTPK T PKGPS 31.28%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
30NPM1NPM_HUMANT237EKTPK T PKGPS 31.28% Swiss-Prot 55.0 View   
31NPM1NPM_HUMANS254AKMQA S IEKGG 17.87% HPRD:01246(in vivo)View   
32NPM1NPM_HUMANS254AKMQA S IEKGG 17.87% Swiss-Prot 55.0 View   
33NPM1NPM_HUMANS254AKMQA S IEKGG 17.87% Phospho.ELM 7.0View   
34NPM1NPM_HUMANS260IEKGG S LPKVE 50.60% Swiss-Prot 55.0 View