Regulatory Network in Protein Phosphorylation
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Substrate: NSFL1C

Description: NSFL1 cofactor p47 (p97 cofactor p47).

Ensembl ID: ENSG00000088833

UniprotKB/SwissProt: NSF1C_HUMAN (Q9UNZ2)

Function: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Golgi apparatus, Golgi stack (By similarity). Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated
PDB:1SS6
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NSFL1C

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NSFL1CNSF1C_HUMANS29RFFLE S AGWDL 33.94%CDC2 HPRD:09425(in vivo)  ViewAnalyzing
2NSFL1CNSF1C_HUMANS74DNRVT S FRDLI 18.54% Swiss-Prot 55.0 (Similarity)View   
3NSFL1CNSF1C_HUMANS114PPRKK S PNELV 35.67% Swiss-Prot 55.0 View   
4NSFL1CNSF1C_HUMANS140ERVTK S PGETS 28.86%CDC2 HPRD:09425(in vitro;in vivo)  ViewAnalyzing
5NSFL1CNSF1C_HUMANS140ERVTK S PGETS 28.86%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
6NSFL1CNSF1C_HUMANS140ERVTK S PGETS 28.86%CDC2 HPRD:09425(in vivo)  ViewAnalyzing
7NSFL1CNSF1C_HUMANS140ERVTK S PGETS 28.86%CDC2 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
8NSFL1CNSF1C_HUMANS165APEEE S AYVAG 28.34% Swiss-Prot 55.0 View   
9NSFL1CNSF1C_HUMANY167EEESA Y VAGEK 10.50% Swiss-Prot 55.0 View   
10NSFL1CNSF1C_HUMANS176EKRQH S SQDVH 22.74% Swiss-Prot 55.0 (Similarity)View   
11NSFL1CNSF1C_HUMANS272VLSTS S PAQQA 25.09% Phospho.ELM 7.0View   
12NSFL1CNSF1C_HUMANS272VLSTS S PAQQA 25.09% Swiss-Prot 55.0 View