Regulatory Network in Protein Phosphorylation
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Substrate: ORC1L

Description: Origin recognition complex subunit 1 (Replication control protein 1).

Synonyms: ORC1, PARC1

Ensembl ID: ENSG00000085840

UniprotKB/SwissProt: ORC1_HUMAN (Q13415)

Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ORC1L

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ORC1LORC1_HUMANS258CASLD S PGRIK 34.25%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
2ORC1LORC1_HUMANS258CASLD S PGRIK 34.25%CDK2 HPRD:03544(in vitro)  ViewAnalyzing
3ORC1LORC1_HUMANS273FSEIT S PSKRS 32.60%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
4ORC1LORC1_HUMANS273FSEIT S PSKRS 32.60%CDK2 HPRD:03544(in vitro)  ViewAnalyzing
5ORC1LORC1_HUMANT375NEATS T PHRIR 20.82%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
6ORC1LORC1_HUMANT375NEATS T PHRIR 20.82%CDK2 HPRD:03544(in vitro)  ViewAnalyzing
7ORC1LORC1_HUMANS417PAAEI S DSSSD 23.97% Swiss-Prot 55.0 View   
8ORC1LORC1_HUMANS417PAAEI S DSSSD 23.97% Phospho.ELM 7.0View   
9ORC1LORC1_HUMANS419AEISD S SSDEE 25.58% Phospho.ELM 7.0View   
10ORC1LORC1_HUMANS419AEISD S SSDEE 25.58% Swiss-Prot 55.0 View   
11ORC1LORC1_HUMANS420EISDS S SDEEE 46.96% Phospho.ELM 7.0View   
12ORC1LORC1_HUMANS420EISDS S SDEEE 46.96% Swiss-Prot 55.0 View   
13ORC1LORC1_HUMANS421ISDSS S DEEEA 53.66% Swiss-Prot 55.0 View   
14ORC1LORC1_HUMANS421ISDSS S DEEEA 53.66% Phospho.ELM 7.0View