|Description: Lymphokine-activated killer T-cell-originated protein kinase(EC 184.108.40.206) (T-LAK cell-originated protein kinase) (PDZ-bindingkinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-likeprotein kinase) (Nori-3) (Cancer/testis antigen 84) (CT84).|
Ensembl ID: ENSG00000168078
UniprotKB/SwissProt: TOPK_HUMAN (Q96KB5)
Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: