Regulatory Network in Protein Phosphorylation
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Substrate: PBK

Description: Lymphokine-activated killer T-cell-originated protein kinase(EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-bindingkinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-likeprotein kinase) (Nori-3) (Cancer/testis antigen 84) (CT84).

Synonyms: TOPK

Ensembl ID: ENSG00000168078

UniprotKB/SwissProt: TOPK_HUMAN (Q96KB5)

Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PBK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PBKTOPK_HUMANT9ISNFK T PSKLS 28.76%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
2PBKTOPK_HUMANT9ISNFK T PSKLS 28.76%CDC2 HPRD:17822(in vitro)  ViewAnalyzing
3PBKTOPK_HUMANT9ISNFK T PSKLS 28.76%P14635(Cyclin B1) HPRD:17822(in vitro) ViewAnalyzing
4PBKTOPK_HUMANS59RGLSH S PWAVK 20.82% Swiss-Prot 55.0 View   
5PBKTOPK_HUMANT200ENMTV T DPEAC 36.35% Swiss-Prot 55.0 (Similarity)View