|Description: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alphapolypeptide (EC 126.96.36.199) (Phosphoinositide 3-Kinase-C2-alpha)(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).|
Ensembl ID: ENSG00000011405
UniprotKB/SwissProt: P3C2A_HUMAN (O00443)
Function: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response. May be a downstream effector in insulin signaling cascade.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472 it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to Pu