Regulatory Network in Protein Phosphorylation
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Substrate: PIK3C2A

Description: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alphapolypeptide (EC (Phosphoinositide 3-Kinase-C2-alpha)(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

Ensembl ID: ENSG00000011405

UniprotKB/SwissProt: P3C2A_HUMAN (O00443)

Function: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response. May be a downstream effector in insulin signaling cascade.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472 it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to Pu
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PIK3C2A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PIK3C2AP3C2A_HUMANS259SNLQV S PKSED 17.41% Swiss-Prot 55.0 View   
2PIK3C2AP3C2A_HUMANS259SNLQV S PKSED 17.41%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing