|Description: Membrane-associated phosphatidylinositol transfer protein 1(Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinaldegeneration B homolog).|
Synonyms: DRES9, NIR2, PITPNM
Ensembl ID: ENSG00000110697
UniprotKB/SwissProt: PITM1_HUMAN (O00562)
Function: Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proporti