Regulatory Network in Protein Phosphorylation
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Substrate: PITPNM1

Description: Membrane-associated phosphatidylinositol transfer protein 1(Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinaldegeneration B homolog).

Synonyms: DRES9, NIR2, PITPNM

Ensembl ID: ENSG00000110697

UniprotKB/SwissProt: PITM1_HUMAN (O00562)

Function: Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proporti
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PITPNM1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PITPNM1PITM1_HUMANT59GSGQY T HKVYH 13.82% Swiss-Prot 55.0 (Probable)View   
2PITPNM1PITM1_HUMANT287ASNTG T PDGPE 19.03%CDC2 Swiss-Prot 55.0   ViewAnalyzing
3PITPNM1PITM1_HUMANT287ASNTG T PDGPE 19.03%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
4PITPNM1PITM1_HUMANS300PGPDA S PDASF 30.60% Swiss-Prot 55.0 (Similarity)View   
5PITPNM1PITM1_HUMANS382IDAFA S PVEAE 24.03%CDC2 Swiss-Prot 55.0   ViewAnalyzing
6PITPNM1PITM1_HUMANS382IDAFA S PVEAE 24.03%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
7PITPNM1PITM1_HUMANT389VEAEG T PEPGA 18.91% Phospho.ELM 7.0View   
8PITPNM1PITM1_HUMANS593SSRRG S MNNEL 19.27% Swiss-Prot 55.0 View   
9PITPNM1PITM1_HUMANS600NNELL S PEFGP 34.70% Swiss-Prot 55.0 View   
10PITPNM1PITM1_HUMANS621GLGRG S PEPSA 25.40% Swiss-Prot 55.0 View   
11PITPNM1PITM1_HUMANS621GLGRG S PEPSA 25.40% Phospho.ELM 7.0View   
12PITPNM1PITM1_HUMANS621GLGRG S PEPSA 25.40% HPRD:07497(in vivo)View   
13PITPNM1PITM1_HUMANS638PSDMA S PEPEG 24.14% Phospho.ELM 7.0View   
14PITPNM1PITM1_HUMANT794MLVPS T PTSTS 25.23%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
15PITPNM1PITM1_HUMANS896EPSIY S PAFPR 14.21% Swiss-Prot 55.0 View   
16PITPNM1PITM1_HUMANS896EPSIY S PAFPR 14.21% Phospho.ELM 7.0View   
17PITPNM1PITM1_HUMANT1223REGPG T PPTTL 29.27%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing