Regulatory Network in Protein Phosphorylation
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Substrate: PLEC1

Description: Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1) (Plectin-11).

Ensembl ID: ENSG00000178209

UniprotKB/SwissProt: PLEC1_HUMAN (Q15149)

Function: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1MB8
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLEC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLEC1PLEC1_HUMANS125QGPLG S PPKRG 45.79% Swiss-Prot 55.0 View   
2PLEC1PLEC1_HUMANS125QGPLG S PPKRG 45.79% Phospho.ELM 7.0View   
3PLEC1PLEC1_HUMANS149ELEEV S PETPV 21.94% Swiss-Prot 55.0 View   
4PLEC1PLEC1_HUMANS149ELEEV S PETPV 21.94% Phospho.ELM 7.0View   
5PLEC1PLEC1_HUMANS720DEGQL S PATRG 12.47% Phospho.ELM 7.0View   
6PLEC1PLEC1_HUMANS720DEGQL S PATRG 12.47% HPRD:03180(in vivo)View   
7PLEC1PLEC1_HUMANS720DEGQL S PATRG 12.47% Swiss-Prot 55.0 View   
8PLEC1PLEC1_HUMANS782VGFDW S DRNTN 28.65%