Regulatory Network in Protein Phosphorylation
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Substrate: PRC1

Description: Protein regulator of cytokinesis 1.

Ensembl ID: ENSG00000198901

UniprotKB/SwissProt: PRC1_HUMAN (O43663)

Function: KIF4A translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Acts as a microtubule-binding and bundling protein both in vivo and vitro. May function as an in vivo cyclin- CDK substrate.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRC1PRC1_HUMANS195HTPDT S FERDV 32.27% Swiss-Prot 55.0 View   
2PRC1PRC1_HUMANS195HTPDT S FERDV 32.27% HPRD:17899(in vivo)View   
3PRC1PRC1_HUMANS195HTPDT S FERDV 32.27% Phospho.ELM 7.0View   
4PRC1PRC1_HUMANT470GSAPR T PSKRR 30.75%CDK2 HPRD:17899(in vitro;in vivo)  ViewAnalyzing
5PRC1PRC1_HUMANT470GSAPR T PSKRR 30.75%CDK2 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
6PRC1PRC1_HUMANT481GLAPN T PGKAR 32.15%CDK2 HPRD:17899(in vitro;in vivo)  ViewAnalyzing
7PRC1PRC1_HUMANT481GLAPN T PGKAR 32.15% Swiss-Prot 55.0 View   
8PRC1PRC1_HUMANS592SLSDS S TVGLQ 31.91% HPRD:17899(in vivo)View   
9PRC1PRC1_HUMANS592SLSDS S TVGLQ 31.91% Swiss-Prot 55.0 View   
10PRC1PRC1_HUMANS592SLSDS S TVGLQ 31.91% Phospho.ELM 7.0View