Regulatory Network in Protein Phosphorylation
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Substrate: PRDX1

Description: Peroxiredoxin-1 (EC 1.11.1.15) (Thioredoxin peroxidase 2)(Thioredoxin-dependent peroxide reductase 2) (Proliferation-associatedgene protein) (PAG) (Natural killer cell-enhancing factor A) (NKEF-A).

Synonyms: PAGA, PAGB, TDPX2

Ensembl ID: ENSG00000117450

UniprotKB/SwissProt: PRDX1_HUMAN (Q06830)

Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRDX1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRDX1PRDX1_HUMANT90LAWVN T PKKQG 27.19%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2PRDX1PRDX1_HUMANT90LAWVN T PKKQG 27.19%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3PRDX1PRDX1_HUMANT183KPGSD T IKPDV 32.37% Swiss-Prot 55.0 View   
4PRDX1PRDX1_HUMANY194QKSKE Y FSKQK 19.52% Swiss-Prot 55.0 View   
5PRDX1PRDX1_HUMANY194QKSKE Y FSKQK 19.52% Phospho.ELM 7.0View