|Description: Peroxiredoxin-1 (EC 220.127.116.11) (Thioredoxin peroxidase 2)(Thioredoxin-dependent peroxide reductase 2) (Proliferation-associatedgene protein) (PAG) (Natural killer cell-enhancing factor A) (NKEF-A).|
Synonyms: PAGA, PAGB, TDPX2
Ensembl ID: ENSG00000117450
UniprotKB/SwissProt: PRDX1_HUMAN (Q06830)
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.