Regulatory Network in Protein Phosphorylation
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Substrate: PTTG1

Description: Securin (Pituitary tumor-transforming protein 1) (Tumor-transformingprotein 1) (Esp1-associated protein) (hPTTG).

Synonyms: EAP1, PTTG, TUTR1

Ensembl ID: ENSG00000164611

UniprotKB/SwissProt: PTTG1_HUMAN (O95997)

Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTTG1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTTG1PTTG1_HUMANS165QLGPP S PVKMP 45.52%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2PTTG1PTTG1_HUMANS165QLGPP S PVKMP 45.52%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3PTTG1PTTG1_HUMANS165QLGPP S PVKMP 45.52%CDC2 HPRD:04998(in vitro;in vivo)  ViewAnalyzing
4PTTG1PTTG1_HUMANS165QLGPP S PVKMP 45.52% HPRD:04998(in vivo)View