Regulatory Network in Protein Phosphorylation
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Substrate: RBL1

Description: Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associatedprotein) (p107) (PRB1).

Ensembl ID: ENSG00000080839

UniprotKB/SwissProt: RBL1_HUMAN (P28749)

Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Potential).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RBL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11%CDK2 Swiss-Prot 55.0   ViewAnalyzing
2RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11% Phospho.ELM 7.0View   
3RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11% HPRD:00312(in vivo)View   
4RBL1RBL1_HUMANT340KFTRD T PLGKL 19.68% HPRD:00312(in vivo)View   
5RBL1RBL1_HUMANT340KFTRD T PLGKL 19.68% Phospho.ELM 7.0View   
6RBL1RBL1_HUMANT369SFAPS T PLTGR 22.66%CDK4 Swiss-Prot 55.0   ViewAnalyzing