Regulatory Network in Protein Phosphorylation
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Substrate: RBL1

Description: Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associatedprotein) (p107) (PRB1).

Ensembl ID: ENSG00000080839

UniprotKB/SwissProt: RBL1_HUMAN (P28749)

Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Potential).
PDB:1H28
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RBL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11%CDK2 Swiss-Prot 55.0   ViewAnalyzing
2RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11% Phospho.ELM 7.0View   
3RBL1RBL1_HUMANT332EEEIG T PRKFT 26.11% HPRD:00312(in vivo)View   
4RBL1RBL1_HUMANT340KFTRD T PLGKL 19.68% HPRD:00312(in vivo)View   
5RBL1RBL1_HUMANT340KFTRD T PLGKL 19.68% Phospho.ELM 7.0View   
6RBL1RBL1_HUMANT369SFAPS T PLTGR 22.66%CDK4 Swiss-Prot 55.0   ViewAnalyzing
7RBL1RBL1_HUMANT369SFAPS T PLTGR 22.66%CDK4 HPRD:00312(in vivo)  ViewAnalyzing
8RBL1RBL1_HUMANT369SFAPS T PLTGR 22.66%CDK4 Phospho.ELM 7.0  ViewAnalyzing
9RBL1RBL1_HUMANT385KEAVI T PVASA 12.71% HPRD:00312(in vivo)View   
10RBL1RBL1_HUMANT385KEAVI T PVASA 12.71%CDK2 Swiss-Prot 55.0   ViewAnalyzing
11RBL1RBL1_HUMANT385KEAVI T PVASA 12.71% Phospho.ELM 7.0View   
12RBL1RBL1_HUMANS615PLMPM S PLMHP 14.71% HPRD:00312(in vivo)View   
13RBL1RBL1_HUMANS615PLMPM S PLMHP 14.71% Phospho.ELM 7.0View   
14RBL1RBL1_HUMANS640DMQPL S PISVH 27.20%CDK2 Swiss-Prot 55.0   ViewAnalyzing
15RBL1RBL1_HUMANS640DMQPL S PISVH 27.20%CDK4 Swiss-Prot 55.0   ViewAnalyzing
16RBL1RBL1_HUMANS640DMQPL S PISVH 27.20% HPRD:00312(in vivo)View   
17RBL1RBL1_HUMANS640DMQPL S PISVH 27.20%CDK4 Phospho.ELM 7.0  ViewAnalyzing
18RBL1RBL1_HUMANS650HERYS S PTAGS 19.82% Swiss-Prot 55.0 View   
19RBL1RBL1_HUMANS650HERYS S PTAGS 19.82%CDK4 HPRD:00312(in vivo)  ViewAnalyzing
20RBL1RBL1_HUMANS650HERYS S PTAGS 19.82%CDK4 Phospho.ELM 7.0  ViewAnalyzing
21RBL1RBL1_HUMANS749ESKVK S PVSLT 33.26% HPRD:00312(in vivo)View   
22RBL1RBL1_HUMANS749ESKVK S PVSLT 33.26% Phospho.ELM 7.0View   
23RBL1RBL1_HUMANS762SLIGA S PKQTN 27.67% Phospho.ELM 7.0View   
24RBL1RBL1_HUMANS762SLIGA S PKQTN 27.67%CDK2 Swiss-Prot 55.0   ViewAnalyzing
25RBL1RBL1_HUMANS762SLIGA S PKQTN 27.67% HPRD:00312(in vivo)View   
26RBL1RBL1_HUMANS964DAPPL S PFPHI 30.21%CDK2 Swiss-Prot 55.0   ViewAnalyzing
27RBL1RBL1_HUMANS964DAPPL S PFPHI 30.21%CDK4 Swiss-Prot 55.0   ViewAnalyzing
28RBL1RBL1_HUMANS964DAPPL S PFPHI 30.21%CDK4 Phospho.ELM 7.0  ViewAnalyzing
29RBL1RBL1_HUMANS964DAPPL S PFPHI 30.21%CDK4 HPRD:00312(in vivo)  ViewAnalyzing
30RBL1RBL1_HUMANS975KQQPG S PRRIS 23.16%CDK4 Phospho.ELM 7.0  ViewAnalyzing
31RBL1RBL1_HUMANS975KQQPG S PRRIS 23.16%CDK2 Swiss-Prot 55.0   ViewAnalyzing
32RBL1RBL1_HUMANS975KQQPG S PRRIS 23.16% HPRD:00312(in vivo)View   
33RBL1RBL1_HUMANS975KQQPG S PRRIS 23.16%CDK4 Swiss-Prot 55.0   ViewAnalyzing
34RBL1RBL1_HUMANS988HSIYI S PHKNG 12.18%CDK2 Swiss-Prot 55.0   ViewAnalyzing
35RBL1RBL1_HUMANS988HSIYI S PHKNG 12.18% Phospho.ELM 7.0View   
36RBL1RBL1_HUMANS988HSIYI S PHKNG 12.18% HPRD:00312(in vivo)View   
37RBL1RBL1_HUMANT997NGSGL T PRSAL 21.85% HPRD:00312(in vivo)View   
38RBL1RBL1_HUMANT997NGSGL T PRSAL 21.85%CDK2 Swiss-Prot 55.0   ViewAnalyzing
39RBL1RBL1_HUMANT997NGSGL T PRSAL 21.85% Phospho.ELM 7.0View   
40RBL1RBL1_HUMANS1009YKFNG S PSKSL 27.40% Phospho.ELM 7.0View   
41RBL1RBL1_HUMANS1009YKFNG S PSKSL 27.40% HPRD:00312(in vivo)View   
42RBL1RBL1_HUMANS1009YKFNG S PSKSL 27.40%CDK2 Swiss-Prot 55.0   ViewAnalyzing
43RBL1RBL1_HUMANS1041DSDAE S PAKRV 31.70% Phospho.ELM 7.0View   
44RBL1RBL1_HUMANS1041DSDAE S PAKRV 31.70% HPRD:00312(in vivo)View