Regulatory Network in Protein Phosphorylation
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Substrate: RBL2

Description: Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associatedprotein) (p130) (PRB2) (RBR-2).

Synonyms: RB2

Ensembl ID: ENSG00000103479

UniprotKB/SwissProt: RBL2_HUMAN (Q08999)

Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RBL2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RBL2RBL2_HUMANT401ALRIS T PLTGV 21.68% HPRD:01576(in vivo)View   
2RBL2RBL2_HUMANT401ALRIS T PLTGV 21.68%CDK4 Phospho.ELM 7.0  ViewAnalyzing
3RBL2RBL2_HUMANT401ALRIS T PLTGV 21.68%CDK6 Phospho.ELM 7.0  ViewAnalyzing
4RBL2RBL2_HUMANS413YIKEN S PCVTP 22.29% Swiss-Prot 55.0 (Similarity)View   
5RBL2RBL2_HUMANS413YIKEN S PCVTP 22.29%CDK2 Phospho.ELM 7.0  ViewAnalyzing
6RBL2RBL2_HUMANS413YIKEN S PCVTP 22.29% HPRD:01576(in vivo)View   
7RBL2RBL2_HUMANS413YIKEN S PCVTP 22.29%CDK_group Phospho.ELM 7.0 ViewAnalyzing
8RBL2RBL2_HUMANT417NSPCV T PVSTA 25.37% HPRD:01576(in vivo)View   
9RBL2RBL2_HUMANT417NSPCV T PVSTA 25.37%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10RBL2RBL2_HUMANT417NSPCV T PVSTA 25.37% Swiss-Prot 55.0 (Similarity)View   
11RBL2RBL2_HUMANT417NSPCV T PVSTA 25.37%CDK2 Phospho.ELM 7.0  ViewAnalyzing
12RBL2RBL2_HUMANS639ICIAG S PLTPR 14.02% HPRD:01576(in vivo)View   
13RBL2RBL2_HUMANS639ICIAG S PLTPR 14.02% Swiss-Prot 55.0 View   
14RBL2RBL2_HUMANS639ICIAG S PLTPR 14.02%CDK2 Phospho.ELM 7.0  ViewAnalyzing
15RBL2RBL2_HUMANT642AGSPL T PRRVT 20.38%CDK2 Phospho.ELM 7.0  ViewAnalyzing
16RBL2RBL2_HUMANT642AGSPL T PRRVT 20.38% HPRD:01576(in vivo)View   
17RBL2RBL2_HUMANT642AGSPL T PRRVT 20.38%CDK_group Phospho.ELM 7.0 ViewAnalyzing
18RBL2RBL2_HUMANT642AGSPL T PRRVT 20.38% Swiss-Prot 55.0 (Similarity)View   
19RBL2RBL2_HUMANS662GRSIT S PTTLY 20.69%CDK2 Phospho.ELM 7.0  ViewAnalyzing
20RBL2RBL2_HUMANS662GRSIT S PTTLY 20.69%CDK_group Phospho.ELM 7.0 ViewAnalyzing
21RBL2RBL2_HUMANS662GRSIT S PTTLY 20.69% HPRD:01576(in vivo)View   
22RBL2RBL2_HUMANS672YDRYS S PPAST 26.43% HPRD:01576(in vivo)View   
23RBL2RBL2_HUMANS672YDRYS S PPAST 26.43% Swiss-Prot 55.0 View   
24RBL2RBL2_HUMANS672YDRYS S PPAST 26.43%CDK4 Phospho.ELM 7.0  ViewAnalyzing
25RBL2RBL2_HUMANS672YDRYS S PPAST 26.43%CDK6 Phospho.ELM 7.0  ViewAnalyzing
26RBL2RBL2_HUMANS688FVEND S PSDGG 37.57% HPRD:01576(in vivo)View   
27RBL2RBL2_HUMANS688FVEND S PSDGG 37.57%CDK_group Phospho.ELM 7.0 ViewAnalyzing
28RBL2RBL2_HUMANS688FVEND S PSDGG 37.57%CDK2 Phospho.ELM 7.0  ViewAnalyzing
29RBL2RBL2_HUMANT694PSDGG T PGRMP 28.26%CDK_group Phospho.ELM 7.0 ViewAnalyzing
30RBL2RBL2_HUMANT694PSDGG T PGRMP 28.26% HPRD:01576(in vivo)View   
31RBL2RBL2_HUMANT694PSDGG T PGRMP 28.26%CDK2 Phospho.ELM 7.0  ViewAnalyzing
32RBL2RBL2_HUMANS948SSDSR S HQNSP 33.12% Swiss-Prot 55.0 (Similarity)View   
33RBL2RBL2_HUMANS948SSDSR S HQNSP 33.12% Phospho.ELM 7.0View   
34RBL2RBL2_HUMANS948SSDSR S HQNSP 33.12% HPRD:01576(in vivo)View   
35RBL2RBL2_HUMANS952RSHQN S PTELN 26.99% Swiss-Prot 55.0 View   
36RBL2RBL2_HUMANS952RSHQN S PTELN 26.99% HPRD:01576(in vivo)View   
37RBL2RBL2_HUMANS952RSHQN S PTELN 26.99%CDK2 Phospho.ELM 7.0  ViewAnalyzing
38RBL2RBL2_HUMANS962NKDRT S RDSSP 34.68% Phospho.ELM 7.0View   
39RBL2RBL2_HUMANS962NKDRT S RDSSP 34.68% HPRD:01576(in vivo)View   
40RBL2RBL2_HUMANS966TSRDS S PVMRS 26.29% Phospho.ELM 7.0View   
41RBL2RBL2_HUMANS966TSRDS S PVMRS 26.29% Swiss-Prot 55.0 View   
42RBL2RBL2_HUMANS966TSRDS S PVMRS 26.29% HPRD:01576(in vivo)View   
43RBL2RBL2_HUMANS971SPVMR S SSTLP 15.56% Swiss-Prot 55.0 (Probable)View   
44RBL2RBL2_HUMANS971SPVMR S SSTLP 15.56% Phospho.ELM 7.0View   
45RBL2RBL2_HUMANS971SPVMR S SSTLP 15.56% HPRD:01576(in vivo)View   
46RBL2RBL2_HUMANS972PVMRS S STLPV 19.58% Swiss-Prot 55.0 (Probable)View   
47RBL2RBL2_HUMANS972PVMRS S STLPV 19.58% Phospho.ELM 7.0View   
48RBL2RBL2_HUMANS972PVMRS S STLPV 19.58% HPRD:01576(in vivo)View   
49RBL2RBL2_HUMANS973VMRSS S TLPVP 34.90% HPRD:01576(in vivo)View   
50RBL2RBL2_HUMANS973VMRSS S TLPVP 34.90% Swiss-Prot 55.0 (Probable)View   
51RBL2RBL2_HUMANS973VMRSS S TLPVP 34.90%CDK2 Phospho.ELM 7.0  ViewAnalyzing
52RBL2RBL2_HUMANT974MRSSS T LPVPQ 36.71% Phospho.ELM 7.0View   
53RBL2RBL2_HUMANT974MRSSS T LPVPQ 36.71% HPRD:01576(in vivo)View   
54RBL2RBL2_HUMANT974MRSSS T LPVPQ 36.71% Swiss-Prot 55.0 (Probable)View   
55RBL2RBL2_HUMANS981PVPQP S SAPPT 33.61% Phospho.ELM 7.0View   
56RBL2RBL2_HUMANS981PVPQP S SAPPT 33.61% HPRD:01576(in vivo)View   
57RBL2RBL2_HUMANS981PVPQP S SAPPT 33.61% Swiss-Prot 55.0 (Probable)View   
58RBL2RBL2_HUMANS982VPQPS S APPTP 52.02%CDK2 Phospho.ELM 7.0  ViewAnalyzing
59RBL2RBL2_HUMANS982VPQPS S APPTP 52.02% Swiss-Prot 55.0 (Probable)View   
60RBL2RBL2_HUMANS982VPQPS S APPTP 52.02% HPRD:01576(in vivo)View   
61RBL2RBL2_HUMANT986SSAPP T PTRLT 35.91% Phospho.ELM 7.0View   
62RBL2RBL2_HUMANT986SSAPP T PTRLT 35.91% HPRD:01576(in vivo)View   
63RBL2RBL2_HUMANT986SSAPP T PTRLT 35.91% Swiss-Prot 55.0 View   
64RBL2RBL2_HUMANT1019IKQIK T FAMKY 20.46% Swiss-Prot 55.0 View   
65RBL2RBL2_HUMANS1035DAPPL S PYPFV 28.32% HPRD:01576(in vivo)View   
66RBL2RBL2_HUMANS1035DAPPL S PYPFV 28.32%CDK4 Phospho.ELM 7.0  ViewAnalyzing
67RBL2RBL2_HUMANS1035DAPPL S PYPFV 28.32%CDK6 Phospho.ELM 7.0  ViewAnalyzing
68RBL2RBL2_HUMANS1044FVRTG S PRRIQ 18.02%CDK2 Phospho.ELM 7.0  ViewAnalyzing
69RBL2RBL2_HUMANS1044FVRTG S PRRIQ 18.02%CDK_group Phospho.ELM 7.0 ViewAnalyzing
70RBL2RBL2_HUMANS1044FVRTG S PRRIQ 18.02% HPRD:01576(in vivo)View   
71RBL2RBL2_HUMANS1068NETML S PREKI 15.87% HPRD:01576(in vivo)View   
72RBL2RBL2_HUMANS1068NETML S PREKI 15.87%CDK2 Phospho.ELM 7.0  ViewAnalyzing
73RBL2RBL2_HUMANS1068NETML S PREKI 15.87%CDK_group Phospho.ELM 7.0 ViewAnalyzing
74RBL2RBL2_HUMANS1080YYFSN S PSKRL 29.38%CDK2 Phospho.ELM 7.0  ViewAnalyzing
75RBL2RBL2_HUMANS1080YYFSN S PSKRL 29.38% HPRD:01576(in vivo)View   
76RBL2RBL2_HUMANS1080YYFSN S PSKRL 29.38%CDK_group Phospho.ELM 7.0 ViewAnalyzing
77RBL2RBL2_HUMANT1097IRTGE T PTKKR 37.29%CDK2 Phospho.ELM 7.0  ViewAnalyzing
78RBL2RBL2_HUMANT1097IRTGE T PTKKR 37.29% HPRD:01576(in vivo)View   
79RBL2RBL2_HUMANT1097IRTGE T PTKKR 37.29%CDK_group Phospho.ELM 7.0 ViewAnalyzing
80RBL2RBL2_HUMANS1112EDGSE S PAKRI 31.67%CDK2 Phospho.ELM 7.0  ViewAnalyzing
81RBL2RBL2_HUMANS1112EDGSE S PAKRI 31.67% HPRD:01576(in vivo)View   
82RBL2RBL2_HUMANS1112EDGSE S PAKRI 31.67%CDK_group Phospho.ELM 7.0 ViewAnalyzing