Regulatory Network in Protein Phosphorylation
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Substrate: RCC1

Description: Regulator of chromosome condensation (Chromosome condensation protein1) (Cell cycle regulatory protein).

Synonyms: CHC1

Ensembl ID: ENSG00000180198

UniprotKB/SwissProt: RCC1_HUMAN (P18754)

Function: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis.
PDB:1A12
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RCC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RCC1RCC1_HUMANS2----M S PKRIA 38.85%CDC2 HPRD:01559(in vitro)  ViewAnalyzing
2RCC1RCC1_HUMANS11IAKRR S PPADA 38.99% Swiss-Prot 55.0 View   
3RCC1RCC1_HUMANS11IAKRR S PPADA 38.99% Phospho.ELM 7.0View   
4RCC1RCC1_HUMANS11IAKRR S PPADA 38.99% HPRD:01559(in vivo)View   
5RCC1RCC1_HUMANS403NRVVL S VSSGG 14.35% Swiss-Prot 55.0 View   
6RCC1RCC1_HUMANS405VVLSV S SGGQH 21.64% Swiss-Prot 55.0 View   
7RCC1RCC1_HUMANS406VLSVS S GGQHT 44.80% Swiss-Prot 55.0 View   
8RCC1RCC1_HUMANT411SGGQH T VLLVK 12.64% Swiss-Prot 55.0 View