Regulatory Network in Protein Phosphorylation
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Substrate: RRM2

Description: Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1)(Ribonucleotide reductase small subunit) (Ribonucleotide reductasesmall chain).

Synonyms: RR2

Ensembl ID: ENSG00000171848

UniprotKB/SwissProt: RIR2_HUMAN (P31350)

Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:2UW2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RRM2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RRM2RIR2_HUMANS20QQLQL S PLKGL 18.41% Swiss-Prot 55.0 View   
2RRM2RIR2_HUMANS20QQLQL S PLKGL 18.41%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3RRM2RIR2_HUMANS20QQLQL S PLKGL 18.41%CDC2 HPRD:01587(in vitro)  ViewAnalyzing