Regulatory Network in Protein Phosphorylation
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Substrate: SF3B1

Description: Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

Synonyms: SAP155

Ensembl ID: ENSG00000115524

UniprotKB/SwissProt: SF3B1_HUMAN (O75533)

Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
PDB:2F9D
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SF3B1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SF3B1SF3B1_HUMANS129RTMII S PERLD 15.13% Phospho.ELM 7.0View   
2SF3B1SF3B1_HUMANT142ADGGK T PDPKM 35.88% Swiss-Prot 55.0 View   
3SF3B1SF3B1_HUMANT207QTADQ T PGATP 25.00% Phospho.ELM 7.0View   
4SF3B1SF3B1_HUMANT207QTADQ T PGATP 25.00% Swiss-Prot 55.0 View   
5SF3B1SF3B1_HUMANT211QTPGA T PKKLS 41.37% Swiss-Prot 55.0 View   
6SF3B1SF3B1_HUMANT211QTPGA T PKKLS 41.37% Phospho.ELM 7.0View   
7SF3B1SF3B1_HUMANS217PKKLS S WDQAE 45.14% Phospho.ELM 7.0View   
8SF3B1SF3B1_HUMANT223WDQAE T PGHTP 37.27% Swiss-Prot 55.0 View   
9SF3B1SF3B1_HUMANT223WDQAE T PGHTP 37.27% Phospho.ELM 7.0View   
10SF3B1SF3B1_HUMANT227ETPGH T PSLRW 22.08% Phospho.ELM 7.0View   
11SF3B1SF3B1_HUMANT227ETPGH T PSLRW 22.08% Swiss-Prot 55.0 (Similarity)View   
12SF3B1SF3B1_HUMANT235LRWDE T PGRAK 28.68% Phospho.ELM 7.0View   
13SF3B1SF3B1_HUMANT235LRWDE T PGRAK 28.68% Swiss-Prot 55.0 View   
14SF3B1SF3B1_HUMANT244AKGSE T PGATP 28.81% Swiss-Prot 55.0 View   
15SF3B1SF3B1_HUMANT244AKGSE T PGATP 28.81%CDK2 Phospho.ELM 7.0  ViewAnalyzing
16SF3B1SF3B1_HUMANT248ETPGA T PGSKI 33.81% Swiss-Prot 55.0 (Probable)View   
17SF3B1SF3B1_HUMANT248ETPGA T PGSKI 33.81%CDK2 Phospho.ELM 7.0  ViewAnalyzing
18SF3B1SF3B1_HUMANT267PAGAA T PGRGD 26.24% Swiss-Prot 55.0 (Similarity)View   
19SF3B1SF3B1_HUMANT296NRWDE T PKTER 27.84% Swiss-Prot 55.0 View   
20SF3B1SF3B1_HUMANT296NRWDE T PKTER 27.84% Phospho.ELM 7.0View   
21SF3B1SF3B1_HUMANT299DETPK T ERDTP 37.14% Phospho.ELM 7.0View   
22SF3B1SF3B1_HUMANT299DETPK T ERDTP 37.14% Swiss-Prot 55.0 View   
23SF3B1SF3B1_HUMANT303KTERD T PGHGS 37.07% Phospho.ELM 7.0View   
24SF3B1SF3B1_HUMANT313SGWAE T PRTDR 15.43% Swiss-Prot 55.0 (Probable)View   
25SF3B1SF3B1_HUMANT313SGWAE T PRTDR 15.43%CDK2 Phospho.ELM 7.0  ViewAnalyzing
26SF3B1SF3B1_HUMANT316AETPR T DRGGD 31.11% Phospho.ELM 7.0View   
27SF3B1SF3B1_HUMANT316AETPR T DRGGD 31.11% Swiss-Prot 55.0 View   
28SF3B1SF3B1_HUMANT326DSIGE T PTPGA 27.52% Swiss-Prot 55.0 View   
29SF3B1SF3B1_HUMANT326DSIGE T PTPGA 27.52% Phospho.ELM 7.0View   
30SF3B1SF3B1_HUMANT328IGETP T PGASK 41.60% Swiss-Prot 55.0 View   
31SF3B1SF3B1_HUMANS344DETPA S QMGGS 23.15% Swiss-Prot 55.0 View   
32SF3B1SF3B1_HUMANS344DETPA S QMGGS 23.15% Phospho.ELM 7.0View   
33SF3B1SF3B1_HUMANS344DETPA S QMGGS 23.15% HPRD:09281(in vivo)View   
34SF3B1SF3B1_HUMANS349SQMGG S TPVLT 24.65% Phospho.ELM 7.0View   
35SF3B1SF3B1_HUMANT350QMGGS T PVLTP 22.23% HPRD:09281(in vivo)View   
36SF3B1SF3B1_HUMANT350QMGGS T PVLTP 22.23% Phospho.ELM 7.0View   
37SF3B1SF3B1_HUMANT350QMGGS T PVLTP 22.23% Swiss-Prot 55.0 View   
38SF3B1SF3B1_HUMANT354STPVL T PGKTP 30.17% Phospho.ELM 7.0View   
39SF3B1SF3B1_HUMANT354STPVL T PGKTP 30.17% Swiss-Prot 55.0 View   
40SF3B1SF3B1_HUMANT354STPVL T PGKTP 30.17% HPRD:09281(in vivo)View   
41SF3B1SF3B1_HUMANT434RKLTA T PTPLG 23.59%DYRK1A HPRD:09281(in vitro;in vivo)  ViewAnalyzing
42SF3B1SF3B1_HUMANT434RKLTA T PTPLG 23.59% Phospho.ELM 7.0View   
43SF3B1SF3B1_HUMANT436LTATP T PLGGM 27.13% Phospho.ELM 7.0View