|Description: Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).|
Ensembl ID: ENSG00000115524
UniprotKB/SwissProt: SF3B1_HUMAN (O75533)
Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.