Regulatory Network in Protein Phosphorylation
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Substrate: SLBP

Description: Histone RNA hairpin-binding protein (Histone stem-loop-bindingprotein).

Synonyms: HBP

Ensembl ID: ENSG00000163950

UniprotKB/SwissProt: SLBP_HUMAN (Q14493)

Function: Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Could play an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Polyribosome- associated.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SLBP

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SLBPSLBP_HUMANS7ACRPR S PPRHQ 41.77% Phospho.ELM 7.0View   
2SLBPSLBP_HUMANS20CDGDA S PPSPA 41.92% Swiss-Prot 55.0 View   
3SLBPSLBP_HUMANS20CDGDA S PPSPA 41.92% Phospho.ELM 7.0View   
4SLBPSLBP_HUMANS23DASPP S PARWS 34.28% Phospho.ELM 7.0View   
5SLBPSLBP_HUMANS23DASPP S PARWS 34.28% Swiss-Prot 55.0 View   
6SLBPSLBP_HUMANT61RPESF T TPEGP 51.20% Phospho.ELM 7.0View   
7SLBPSLBP_HUMANT61RPESF T TPEGP 51.20% HPRD:03884(in vitro)View   
8SLBPSLBP_HUMANT62PESFT T PEGPK 19.82%CDC2 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
9SLBPSLBP_HUMANT62PESFT T PEGPK 19.82% Phospho.ELM 7.0View   
10SLBPSLBP_HUMANT62PESFT T PEGPK 19.82% HPRD:03884(in vitro)View