Regulatory Network in Protein Phosphorylation
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Substrate: SMAD3

Description: Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3).

Synonyms: MADH3

Ensembl ID: ENSG00000166949

UniprotKB/SwissProt: SMAD3_HUMAN (P84022)

Function: Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
PDB:1MHD
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SMAD3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SMAD3SMAD3_HUMANT8SILPF T PPIVK 26.64%CDK2 HPRD:04380(in vitro;in vivo)  ViewAnalyzing
2SMAD3SMAD3_HUMANT8SILPF T PPIVK 26.64%CDK2 Phospho.ELM 7.0  ViewAnalyzing
3SMAD3SMAD3_HUMANT8SILPF T PPIVK 26.64%CDK4 Phospho.ELM 7.0  ViewAnalyzing
4SMAD3SMAD3_HUMANT8SILPF T PPIVK 26.64%CDK4 HPRD:04380(in vitro;in vivo)  ViewAnalyzing
5SMAD3SMAD3_HUMANT179SNIPE T PPPGY 35.