Regulatory Network in Protein Phosphorylation
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Substrate: TFDP1

Description: Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1-polypeptide 1) (DRTF1).

Synonyms: DP1

UniprotKB/SwissProt: TFDP1_HUMAN (Q14186)

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:2AZE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TFDP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TFDP1TFDP1_HUMANS23IDQNL S PGKGV 38.87%CDK2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
2TFDP1TFDP1_HUMANS183AMNII S KEKKE 30.85% Swiss-Prot 55.0 View