Regulatory Network in Protein Phosphorylation
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Substrate: TFDP2

Description: Transcription factor Dp-2 (E2F dimerization partner 2).

Synonyms: DP2

UniprotKB/SwissProt: TFDP2_HUMAN (Q14188)

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1CF7
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TFDP2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TFDP2TFDP2_HUMANS24IDQNL S PTKGN 37.76%CDK2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
2TFDP2TFDP2_HUMANS42VSNTN S PTKIL 31.72%CDK2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing