Regulatory Network in Protein Phosphorylation
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Substrate: TLE1

Description: Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

Ensembl ID: ENSG00000196781

UniprotKB/SwissProt: TLE1_HUMAN (Q04724)

Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Nuclear and chromatin- associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
PDB:1GXR
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TLE1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TLE1TLE1_HUMANS239SSHYD S DGDKS 36.01%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
2TLE1TLE1_HUMANS239SSHYD S DGDKS 36.01%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
3TLE1TLE1_HUMANS259NEDPS S PRASP 24.64%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
4TLE1TLE1_HUMANS263SSPRA S PAHSP 24.73%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
5TLE1TLE1_HUMANS267ASPAH S PRENG 27.97%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
6TLE1TLE1_HUMANS284LKKDA S SSPAS 41.29% Swiss-Prot 55.0 (Similarity)View