Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase CDK2]
Substrate: TSC1

Description: Hamartin (Tuberous sclerosis 1 protein).

Synonyms: KIAA0243, TSC

Ensembl ID: ENSG00000165699

UniprotKB/SwissProt: TSC1_HUMAN (Q92574)

Function: Implicated as a tumor suppressor. May have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TSC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TSC1TSC1_HUMANT417PQATV T PPRKE 24.18%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
2TSC1TSC1_HUMANT417PQATV T PPRKE 24.18%CDC2 HPRD:05594(in vitro;in vivo)  ViewAnalyzing
3TSC1TSC1_HUMANS505RGGFD S PFYRD 18.04% Swiss-Prot 55.0 View   
4TSC1TSC1_HUMANS505RGGFD S PFYRD 18.04% Phospho.ELM 7.0View   
5TSC1TSC1_HUMANS584SIFTP S PCKIP 39.61%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
6TSC1TSC1_HUMANS584SIFTP S PCKIP 39.61%CDC2 HPRD:05594(in vitro;in vivo)  ViewAnalyzing
7TSC1TSC1_HUMANT1047SSELS T PEKPP 48.36%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
8TSC1TSC1_HUMANT1047SSELS T PEKPP 48.36%CDC2 HPRD:05594(in vitro;in vivo)  ViewAnalyzing
9TSC1TSC1_HUMANS1102RNKSE S QCDED 43.11% Swiss-Prot 55.0 View