Regulatory Network in Protein Phosphorylation
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Substrate: WEE1

Description: Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

Ensembl ID: ENSG00000166483

UniprotKB/SwissProt: WEE1_HUMAN (P30291)

Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDC2 does not occur.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1X8B
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of WEE1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1WEE1WEE1_HUMANS53STGED S AFQEP 27.04%PLK1 Phospho.ELM 7.0  ViewAnalyzing
2WEE1WEE1_HUMANS53STGED S AFQEP 27.04%PLK1 HPRD:01907(in vitro)  ViewAnalyzing
3WEE1WEE1_HUMANS121EEGFG S SSPVK