Regulatory Network in Protein Phosphorylation
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Substrate: ACACA

Description: Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)].

Synonyms: ACAC, ACC1, ACCA

UniprotKB/SwissProt: ACACA_HUMAN (Q13085)

Function: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ACACA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% Swiss-Prot 55.0 View   
2ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% HPRD:01938(in vitro)View   
3ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% Phospho.ELM 7.0View   
4ACACAACACA_HUMANS25IIGSV S EDNSE 40.71% HPRD:01938(in vitro)View   
5ACACAACACA_HUMANS25IIGSV S EDNSE 40.71% Swiss-Prot 55.0 View   
6ACACAACACA_HUMANS25IIGSV S EDNSE 40.71%CaMK1_group Phospho.ELM 7.0 ViewAnalyzing
7ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2a2 HPRD:01938(in vitro)  ViewAnalyzing
8ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% HPRD:01938(in vitro)View   
10ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% HPRD:01938(in vivo)View   
11ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% Swiss-Prot 55.0 View   
12ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2a1 HPRD:01938(in vitro)  ViewAnalyzing
13ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2a1-rs HPRD:01938(in vitro)  ViewAnalyzing
14ACACAACACA_HUMANS48EEKEG S LSPAS 27.11% Phospho.ELM 7.0View   
15ACACAACACA_HUMANS48EEKEG S LSPAS 27.11% Swiss-Prot 55.0 View   
16ACACAACACA_HUMANS50KEGSL S PASVG 21.81% Phospho.ELM 7.0View   
17ACACAACACA_HUMANS50KEGSL S PASVG 21.81% Swiss-Prot 55.0 View   
18ACACAACACA_HUMANS53SLSPA S VGSDT 30.32% Swiss-Prot 55.0 View   
19ACACAACACA_HUMANS53SLSPA S VGSDT 30.32% Phospho.ELM 7.0View   
20ACACAACACA_HUMANS56PASVG S DTLSD 25.85% Phospho.ELM 7.0View   
21ACACAACACA_HUMANS56PASVG S DTLSD 25.85% Swiss-Prot 55.0 View   
22ACACAACACA_HUMANT58SVGSD T LSDLG 29.83% Swiss-Prot 55.0 View   
23ACACAACACA_HUMANT58SVGSD T LSDLG 29.83% Phospho.ELM 7.0View   
24ACACAACACA_HUMANS60GSDTL S DLGIS 32.64% Phospho.ELM 7.0View   
25ACACAACACA_HUMANS60GSDTL S DLGIS 32.64% Swiss-Prot 55.0 View   
26ACACAACACA_HUMANS60GSDTL S DLGIS 32.64% HPRD:01938(in vitro)View   
27ACACAACACA_HUMANS66DLGIS S LQDGL 28.29% HPRD:01938(in vivo)View   
28ACACAACACA_HUMANS66DLGIS S LQDGL 28.29%CK2a2 HPRD:01938(in vitro)  ViewAnalyzing
29ACACAACACA_HUMANS66DLGIS S LQDGL 28.29%CK2a1-rs HPRD:01938(in vitro)  ViewAnalyzing
30ACACAACACA_HUMANS66DLGIS S LQDGL 28.29%CK2a1 HPRD:01938(in vitro)  ViewAnalyzing
31ACACAACACA_HUMANS77ALHIR S SMSGL 29.77% Phospho.ELM 7.0View   
32ACACAACACA_HUMANS78LHIRS S MSGLH 13.71% Swiss-Prot 55.0 (Similarity)View   
33ACACAACACA_HUMANS78LHIRS S MSGLH 13.71%PKA alpha Phospho.ELM 7.0 ViewAnalyzing
34ACACAACACA_HUMANS78LHIRS S MSGLH 13.71% HPRD:01938(in vitro)View   
35ACACAACACA_HUMANS80IRSSM S GLHLV 39.90%AMPKa1 HPRD:01938(in vitro)  ViewAnalyzing
36ACACAACACA_HUMANS80IRSSM S GLHLV 39.90%AMPKa2 HPRD:01938(in vitro)  ViewAnalyzing
37ACACAACACA_HUMANS80IRSSM S GLHLV 39.90%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
38ACACAACACA_HUMANS80IRSSM S GLHLV 39.90% HPRD:01938(in vitro)View   
39ACACAACACA_HUMANS80IRSSM S GLHLV 39.90% Swiss-Prot 55.0 (Similarity)View   
40ACACAACACA_HUMANS80IRSSM S GLHLV 39.90%AMPKa1 HPRD:01938(in vitro)  ViewAnalyzing
41ACACAACACA_HUMANS80IRSSM S GLHLV 39.90% HPRD:01938(in vitro)View   
42ACACAACACA_HUMANS80IRSSM S GLHLV 39.90% HPRD:01938(in vitro)View   
43ACACAACACA_HUMANT1042KNLLV T MLIDQ 13.26% Swiss-Prot 55.0 View   
44ACACAACACA_HUMANS1201TLNRM S FSSNL 20.81%AMPKa1 HPRD:01938(in vitro)  ViewAnalyzing
45ACACAACACA_HUMANS1201TLNRM S FSSNL 20.81%PKA alpha Phospho.ELM 7.0 ViewAnalyzing
46ACACAACACA_HUMANS1201TLNRM S FSSNL 20.81%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
47ACACAACACA_HUMANS1201TLNRM S FSSNL 20.81% HPRD:01938(in vitro)View   
48ACACAACACA_HUMANS1201TLNRM S FSSNL 20.81% Swiss-Prot 55.0 (Similarity)View   
49ACACAACACA_HUMANS1216MTHVA S VSDVL 22.51% HPRD:01938(in vitro)View   
50ACACAACACA_HUMANS1238MGGMV S FRTFE 10.50% HPRD:01938(in vitro)View   
51ACACAACACA_HUMANS1238MGGMV S FRTFE 10.50%AMPKa1 HPRD:01938(in vitro)  ViewAnalyzing
52ACACAACACA_HUMANS1263DSPPQ S PTFPE 31.51% Swiss-Prot 55.0 View   
53ACACAACACA_HUMANS1263DSPPQ S PTFPE 31.51% Phospho.ELM 7.0View   
54ACACAACACA_HUMANS1844IQVEN S HLILT 13.23% Swiss-Prot 55.0 View   
55ACACAACACA_HUMANS2099VVIDS S INPRH 23.72% Swiss-Prot 55.0 View   
56ACACAACACA_HUMANY2108RHMEM Y ADRES 7.64% Swiss-Prot 55.0 View