|Description: Amiloride-sensitive cation channel 3 (Acid-sensing ion channel 3)(ASIC3) (hASIC3) (Testis sodium channel 1) (hTNaC1).|
Synonyms: ASIC3, SLNAC1, TNAC1
Ensembl ID: ENSG00000213199
UniprotKB/SwissProt: ACCN3_HUMAN (Q9UHC3)
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By s