Regulatory Network in Protein Phosphorylation
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Substrate: ACCN3

Description: Amiloride-sensitive cation channel 3 (Acid-sensing ion channel 3)(ASIC3) (hASIC3) (Testis sodium channel 1) (hTNaC1).

Synonyms: ASIC3, SLNAC1, TNAC1

Ensembl ID: ENSG00000213199

UniprotKB/SwissProt: ACCN3_HUMAN (Q9UHC3)

Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By s
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ACCN3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ACCN3ACCN3_HUMANS5-MKPT S GPEEA 61.96%CK2a1 HPRD:10626(in vitro)  ViewAnalyzing
2ACCN3ACCN3_HUMANS5-MKPT S GPEEA 61.96% HPRD:10626(in vitro)View   
3ACCN3ACCN3_HUMANS5-MKPT S GPEEA 61.96%CK2a1-rs HPRD:10626(in vitro)  ViewAnalyzing
4ACCN3ACCN3_HUMANS39GPGSL S LRRGM 22.87% HPRD:10626(in vitro)View   
5ACCN3ACCN3_HUMANS478WNRQH S QRHSS 22.14% HPRD:10626(in vitro)View   
6ACCN3ACCN3_HUMANS493QEGLG S HRTQV 18.16% HPRD:10626(in vitro)View   
7ACCN3ACCN3_HUMANS521KTLSA S HRTCY 15.32% Swiss-Prot 55.0 (Similarity)View