Regulatory Network in Protein Phosphorylation
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Substrate: AKT1

Description: RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT).

Synonyms: PKB, RAC

Ensembl ID: ENSG00000142208

UniprotKB/SwissProt: AKT1_HUMAN (P31749)

Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1).
PDB:1H10
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of AKT1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1AKT1AKT1_HUMANS124DFRSG S PSDNS 23.60% Swiss-Prot 55.0 View   
2AKT1AKT1_HUMANS124DFRSG S PSDNS 23.60% HPRD:01261(in vivo)View   
3AKT1AKT1_HUMANS124DFRSG S PSDNS 23.60% Phospho.ELM 7.0View   
4AKT1AKT1_HUMANS126RSGSP S DNSGA 51.63% Swiss-Prot 55.0 View   
5AKT1AKT1_HUMANS129SPSDN S GAEEM 44.35% HPRD:01261(in vivo)View   
6AKT1AKT1_HUMANS129SPSDN S GAEEM 44.35%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
7AKT1AKT1_HUMANS129SPSDN S GAEEM 44.35% Swiss-Prot 55.0 View   
8AKT1AKT1_HUMANT308GATMK T FCGTP 17.21%PDK1 Phospho.ELM 7.0  ViewAnalyzing
9AKT1AKT1_HUMANT308GATMK T FCGTP 17.21%CaMKK1 HPRD:01261(in vitro)  ViewAnalyzing
10AKT1AKT1_HUMANT308GATMK T FCGTP 17.21%PDK1 Swiss-Prot 55.0   ViewAnalyzing
11AKT1AKT1_HUMANT308GATMK T FCGTP 17.21% HPRD:01261(in vivo)View   
12AKT1AKT1_HUMANT308GATMK T FCGTP 17.21%PDHK1 HPRD:01261(in vivo)  ViewAnalyzing
13AKT1AKT1_HUMANT308GATMK T FCGTP 17.21%PDK1 HPRD:01261(in vitro;in vivo)  ViewAnalyzing
14AKT1AKT1_HUMANY315CGTPE Y LAPEV 14.90%SRC HPRD:01261(in vitro;in vivo)  ViewAnalyzing
15AKT1AKT1_HUMANY326LEDND Y GRAVD 18.11%SRC HPRD:01261(in vitro;in vivo)  ViewAnalyzing
16AKT1AKT1_HUMANT450QMITI T PPDQD 21.81% HPRD:01261(in vivo)View   
17AKT1AKT1_HUMANT450QMITI T PPDQD 21.81% Phospho.ELM 7.0View   
18AKT1AKT1_HUMANT450QMITI T PPDQD 21.81% HPRD:01261(in vitro)View   
19AKT1AKT1_HUMANS473HFPQF S YSASG 16.96% Swiss-Prot 55.0 View   
20AKT1AKT1_HUMANS473HFPQF S YSASG 16.96%PDHK1 HPRD:01261(in vivo)  ViewAnalyzing
21AKT1AKT1_HUMANS473HFPQF S YSASG 16.96%ILK HPRD:01261(in vitro;in vivo)  ViewAnalyzing
22AKT1AKT1_HUMANS473HFPQF S YSASG 16.96%ILK Phospho.ELM 7.0  ViewAnalyzing
23AKT1AKT1_HUMANS473HFPQF S YSASG 16.96%PDK1 HPRD:01261(in vivo)  ViewAnalyzing
24AKT1AKT1_HUMANS473HFPQF S YSASG 16.96%PDK1 Phospho.ELM 7.0  ViewAnalyzing
25AKT1AKT1_HUMANS473HFPQF S YSASG 16.96% HPRD:01261(in vivo)View   
26AKT1AKT1_HUMANS473HFPQF S YSASG 16.96% HPRD:01261(in vitro;in vivo)View   
27AKT1AKT1_HUMANS473HFPQF S YSASG 16.96% HPRD:01261(in vivo)View   
28AKT1AKT1_HUMANY474FPQFS Y SASGT 15.00% Phospho.ELM 7.0View   
29AKT1AKT1_HUMANY474FPQFS Y SASGT 15.00% Swiss-Prot 55.0 View   
30AKT1AKT1_HUMANY474FPQFS Y SASGT 15.00% HPRD:01261(in vitro;in vivo)View