Regulatory Network in Protein Phosphorylation
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Substrate: ARRB2

Description: Beta-arrestin-2 (Arrestin beta 2).

Synonyms: ARB2, ARR2

Ensembl ID: ENSG00000141480

UniprotKB/SwissProt: ARRB2_HUMAN (P32121)

Function: Regulates beta-adrenergic receptor function. Beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ARRB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ARRB2ARRB2_HUMANY48LVDPD Y LKDRK 22.50% Swiss-Prot 55.0 (Similarity)View   
2ARRB2ARRB2_HUMANT382DTNYA T DDDIV 29.60%CK2a2 HPRD:00147(in vitro;in vivo)  ViewAnalyzing
3ARRB2ARRB2_HUMANT382DTNYA T DDDIV 29.60%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4ARRB2ARRB2_HUMANT382DTNYA T DDDIV 29.60%CK2a1 HPRD:00147(in vitro;in vivo)  ViewAnalyzing
5ARRB2ARRB2_HUMANT382DTNYA T DDDIV 29.60%CK2a1-rs HPRD:00147(in vitro;in vivo)  ViewAnalyzing
6ARRB2ARRB2_HUMANT382DTNYA T DDDIV 29.60%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing