Regulatory Network in Protein Phosphorylation
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Substrate: BIK

Description: Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1).

Synonyms: NBK

Ensembl ID: ENSG00000100290

UniprotKB/SwissProt: BIK_HUMAN (Q13323)

Function: Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Intracytoplasmic membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.
PDB:2IPE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BIK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BIKBIK_HUMANS35LGMTD S EEDLD 33.45%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing