Regulatory Network in Protein Phosphorylation
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Substrate: BRCA1

Description: Breast cancer type 1 susceptibility protein (RING finger protein 53).

Synonyms: RNF53

Ensembl ID: ENSG00000012048

UniprotKB/SwissProt: BRCA1_HUMAN (P38398)

Function: Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Mediates E2-dependent ubiquitination. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1JM7
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BRCA1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BRCA1BRCA1_HUMANS281TNTHA S SLQHE 24.79%ATM HPRD:00218(in vitro)  ViewAnalyzing
2BRCA1BRCA1_HUMANS281TNTHA S SLQHE 24.79%ATR HPRD:00218(in vitro)  ViewAnalyzing
3BRCA1BRCA1_HUMANS308EFCNK S KQPGL 23.64%AurA HPRD:00218(in vitro;in vivo)  ViewAnalyzing
4BRCA1BRCA1_HUMANS308EFCNK S KQPGL 23.64%AurA Phospho.ELM 7.0  ViewAnalyzing
5BRCA1BRCA1_HUMANS389EWFSR S DELLG 33.95%P67870(Casein kinase II, beta) HPRD:00218(in vitro) ViewAnalyzing
6BRCA1BRCA1_HUMANS398LGSDD S HDGES 28.59%ATM HPRD:00218(in vivo)  ViewAnalyzing
7BRCA1BRCA1_HUMANT509RKRRP T SGLHP 33.35%AKT1 HPRD:00218(in vitro;in vivo)  ViewAnalyzing
8BRCA1BRCA1_HUMANT509RKRRP T SGLHP 33.35%AKT_group Phospho.ELM 7.0 ViewAnalyzing
9BRCA1BRCA1_HUMANS840HEVNH S RETSI 26.97% Swiss-Prot 55.0 (Similarity)View   
10BRCA1BRCA1_HUMANT967ETGLI T PNKHG 26.33%CDK2 HPRD:00218(in vitro)  ViewAnalyzing
11BRCA1BRCA1_HUMANS988LFPIK S FVKTK 35.67%CHK2 HPRD:00218(in vivo)  ViewAnalyzing
12BRCA1BRCA1_HUMANS988LFPIK S FVKTK 35.67%CHK2 Phospho.ELM 7.0  ViewAnalyzing
13BRCA1BRCA1_HUMANS988LFPIK S FVKTK 35.67%CHK2 HPRD:00218(in vitro;in vivo)  ViewAnalyzing
14BRCA1BRCA1_HUMANS1143GSSHA S QVCSE 20.09%ATR HPRD:00218(in vitro)  ViewAnalyzing
15BRCA1BRCA1_HUMANS1143GSSHA S QVCSE 20.09%ATR Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
16BRCA1BRCA1_HUMANS1189GELSR S PSPFT 26.76% Phospho.ELM 7.0View   
17BRCA1BRCA1_HUMANS1189GELSR S PSPFT 26.76%ATM HPRD:00218(in vivo)  ViewAnalyzing
18BRCA1BRCA1_HUMANS1211AKKLE S SEENL 54.19% Swiss-Prot 55.0 View   
19BRCA1BRCA1_HUMANS1212KKLES S EENLS 39.28% Swiss-Prot 55.0 View   
20BRCA1BRCA1_HUMANS1217SEENL S SEDEE 43.17% Swiss-Prot 55.0 View   
21BRCA1BRCA1_HUMANS1218EENLS S EDEEL 52.84% Swiss-Prot 55.0 View   
22BRCA1BRCA1_HUMANS1239VNNIP S QSTRH 32.73%ATR HPRD:00218(in vitro)  ViewAnalyzing
23BRCA1BRCA1_HUMANS1239VNNIP S QSTRH 32.73% Swiss-Prot 55.0 View   
24BRCA1BRCA1_HUMANS1245QSTRH S TVATE 22.68% Swiss-Prot 55.0 View   
25BRCA1BRCA1_HUMANS1280ILAKA S QEHHL 35.08%ATR Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
26BRCA1BRCA1_HUMANS1280ILAKA S QEHHL 35.08%ATR HPRD:00218(in vitro)  ViewAnalyzing
27BRCA1BRCA1_HUMANS1330RHQSE S QGVGL 37.16% Swiss-Prot 55.0 View   
28BRCA1BRCA1_HUMANS1330RHQSE S QGVGL 37.16%ATM Phospho.ELM 7.0  ViewAnalyzing
29BRCA1BRCA1_HUMANS1330RHQSE S QGVGL 37.16%ATM HPRD:00218(in vitro)  ViewAnalyzing
30BRCA1BRCA1_HUMANS1336QGVGL S DKELV 40.48% Phospho.ELM 7.0View   
31BRCA1BRCA1_HUMANS1336QGVGL S DKELV 40.48% Swiss-Prot 55.0 View   
32BRCA1BRCA1_HUMANS1342DKELV S DDEER 52.55% Swiss-Prot 55.0 View   
33BRCA1BRCA1_HUMANS1387CSGLS S QSDIL 38.45%ATR HPRD:00218(in vitro)  ViewAnalyzing
34BRCA1BRCA1_HUMANS1387CSGLS S QSDIL 38.45%ATM HPRD:00218(in vivo)  ViewAnalyzing
35BRCA1BRCA1_HUMANS1387CSGLS S QSDIL 38.45%ATM Swiss-Prot 55.0   ViewAnalyzing
36BRCA1BRCA1_HUMANS1387CSGLS S QSDIL 38.45%ATR Swiss-Prot 55.0   ViewAnalyzing
37BRCA1BRCA1_HUMANS1387CSGLS S QSDIL 38.45%ATM Phospho.ELM 7.0  ViewAnalyzing
38BRCA1BRCA1_HUMANT1394SDILT T QQRDT 21.18%ATR Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
39BRCA1BRCA1_HUMANT1394SDILT T QQRDT 21.18%ATR HPRD:00218(in vitro)  ViewAnalyzing
40BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATR Swiss-Prot 55.0   ViewAnalyzing
41BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATM HPRD:00218(in vitro)  ViewAnalyzing
42BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATM HPRD:00218(in vitro;in vivo)  ViewAnalyzing
43BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATM Swiss-Prot 55.0   ViewAnalyzing
44BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATM Phospho.ELM 7.0  ViewAnalyzing
45BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATR Phospho.ELM 7.0  ViewAnalyzing
46BRCA1BRCA1_HUMANS1423LEQHG S QPSNS 36.47%ATR HPRD:00218(in vitro)  ViewAnalyzing
47BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATR Phospho.ELM 7.0  ViewAnalyzing
48BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATM Phospho.ELM 7.0  ViewAnalyzing
49BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATM HPRD:00218(in vitro;in vivo)  ViewAnalyzing
50BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATM HPRD:00218(in vitro)  ViewAnalyzing
51BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATM HPRD:00218(in vitro;in vivo)  ViewAnalyzing
52BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATR Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
53BRCA1BRCA1_HUMANS1457KAVLT S QKSSE 31.30%ATR HPRD:00218(in vitro)  ViewAnalyzing
54BRCA1BRCA1_HUMANS1466SEYPI S QNPEG 21.28%ATM HPRD:00218(in vitro)  ViewAnalyzing
55BRCA1BRCA1_HUMANS1466SEYPI S QNPEG 21.28% Swiss-Prot 55.0 View   
56BRCA1BRCA1_HUMANS1466SEYPI S QNPEG 21.28%ATM Phospho.ELM 7.0  ViewAnalyzing
57BRCA1BRCA1_HUMANS1483EVSAD S STSKN 34.92%ATM HPRD:00218(in vitro)  ViewAnalyzing
58BRCA1BRCA1_HUMANS1497GVERS S PSKCP 39.14%CDK2 Phospho.ELM 7.0  ViewAnalyzing
59BRCA1BRCA1_HUMANS1497GVERS S PSKCP 39.14%CDK_group Phospho.ELM 7.0 ViewAnalyzing
60BRCA1BRCA1_HUMANS1497GVERS S PSKCP 39.14%CDK2 HPRD:00218(in vitro;in vivo)  ViewAnalyzing
61BRCA1BRCA1_HUMANS1499ERSSP S KCPSL 49.16% Phospho.ELM 7.0View   
62BRCA1BRCA1_HUMANS1524NRNYP S QEELI 39.60%ATR Phospho.ELM 7.0  ViewAnalyzing
63BRCA1BRCA1_HUMANS1524NRNYP S QEELI 39.60%ATM HPRD:00218(in vitro;in vivo)  ViewAnalyzing
64BRCA1BRCA1_HUMANS1524NRNYP S QEELI 39.60%ATM HPRD:00218(in vitro)  ViewAnalyzing
65BRCA1BRCA1_HUMANS1524NRNYP S QEELI 39.60%ATM Swiss-Prot 55.0   ViewAnalyzing
66BRCA1BRCA1_HUMANS1524NRNYP S QEELI 39.60%ATM Phospho.ELM 7.0  ViewAnalyzing
67BRCA1BRCA1_HUMANS1542QQLEE S GPHDL 48.53% Phospho.ELM 7.0View   
68BRCA1BRCA1_HUMANS1542QQLEE S GPHDL 48.53%ATM HPRD:00218(in vivo)  ViewAnalyzing
69BRCA1BRCA1_HUMANS1572GISLF S DDPES 46.53%P67870(Casein kinase II, beta) HPRD:00218(in vitro) ViewAnalyzing
70BRCA1BRCA1_HUMANS1572GISLF S DDPES 46.53%CK2a1-rs HPRD:00218(in vitro)  ViewAnalyzing
71BRCA1BRCA1_HUMANS1572GISLF S DDPES 46.53%CK2a1 HPRD:00218(in vitro)  ViewAnalyzing
72BRCA1BRCA1_HUMANT1700FVCER T LKYFL 12.81% Swiss-Prot 55.0 View   
73BRCA1BRCA1_HUMANT1720SYFWV T QSIKE 13.75% Swiss-Prot 55.0 View