Regulatory Network in Protein Phosphorylation
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Substrate: CALM1

Description: Calmodulin (CaM).

Synonyms: CALM, CAM, CAM1

Ensembl ID: ENSG00000143933

UniprotKB/SwissProt: CALM_HUMAN (P62158)

Function: Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Spindle. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
PDB:1AJI
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CALM1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CALM1CALM_HUMANT45LGQNP T EAELQ 56.21%CaMK4  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2CALM1CALM_HUMANT80RKMKD T DSEEE 35.59%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3CALM1CALM_HUMANY100KDGNG Y ISAAE 8.83% Swiss-Prot 55.0 View   
4CALM1CALM_HUMANY100KDGNG Y ISAAE 8.83%EGFR HPRD:00242(in vitro;in vivo)  ViewAnalyzing
5CALM1CALM_HUMANY100KDGNG Y ISAAE 8.83%EGFR Phospho.ELM 7.0  ViewAnalyzing
6CALM1CALM_HUMANY100KDGNG Y ISAAE 8.83%INSR HPRD:00242(in vitro;in vivo)  ViewAnalyzing
7CALM1CALM_HUMANY100KDGNG Y ISAAE 8.83%InsR Phospho.ELM 7.0  ViewAnalyzing
8CALM1CALM_HUMANS102GNGYI S AAELR 16.97%CK2_group Phospho.ELM 7.0 ViewAnalyzing